激素依赖型乳腺癌的内分泌治疗综述

A. N. Useinova, V. B. Kaliberdenko, S. P. Maryanenko, J. M. Al-Nsour, A. A. Korenkova
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引用次数: 0

摘要

研究目的:提供激素依赖性乳腺癌(hdBC)药物治疗的最新数据,并考虑将新的乳腺癌激素治疗药物引入临床实践的可行性。材料与方法。我们分析了 Pubmed、Springer、Cochrane 图书馆等网站上有关治疗 hdBC 的各类药物药理学特征研究的 80 篇文献,其中 49 篇被纳入本综述。结果。目前,治疗高密度脂蛋白胆固醇血症有多种方法。选择性雌激素受体调节剂和芳香化酶抑制剂是研究最多、使用最频繁的药物。细胞周期蛋白依赖性激酶 4/6 抑制剂可用于一线和二线治疗。目前,人们正密切关注基于肿瘤基因组图谱的新药开发,这是治疗间变性乳腺癌的标准,有助于实现个性化治疗。结论药物的进一步开发为提高 hdBC 的总生存率、更准确的预后、对常规系统治疗的反应以及药物治疗的个体化带来了巨大希望。不过,还需要进一步研究和开发新药。在这方面,将口服选择性雌激素受体降解剂引入临床以及开发可阻断雌激素依赖性和独立雌激素受体信号传导的新药是最有希望的趋势。
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A review of endocrine therapy for hormone-dependent breast cancer
Purpose of the study: to provide current data on pharmacotherapy of hormone-dependent breast cancer (hdBC) and to consider the feasibility of introducing new hormone therapy drugs for breast cancer into clinical practice. Material and Methods. We analyzed 80 publications available Pubmed, Springer, Cochrane Library, etc. concerning the study of pharmacological characteristics of various groups of drugs for the treatment of hdBC, of which 49 were included in this review. Results. Currently, there are several approaches to the treatment of hdBC. Selective estrogen receptor modulators and aromatase inhibitors are the most studied and frequently used drugs. The cyclin-dependent kinase 4/6 inhibitors can be present in both the first- and second-line therapy. Currently, close attention is paid to the development of new drugs based on genomic profiling of the tumor, which is the standard of treatment for hdBC, and contributes to the personalization of therapy. Conclusion. Further development of drugs holds great promise for increasing overall survival and more accurate prognosis, response to conventional systemic therapy, and individualization of pharmacotherapy for hdBC. However, further research and development of new drugs is required. In this regard, the introduction of oral selective estrogen receptor degraders into practice and the development of new drugs that block estrogen-dependent and independent signaling to estrogen receptors are the most promising trends.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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