传统草药配方(Azaraghi Majoon)对雄性大鼠鸦片使用障碍的影响

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Advances in Traditional Medicine Pub Date : 2024-07-06 DOI:10.1007/s13596-024-00771-0
Tayyebe Tavakoli, Leila Mohammad Taghizadeh kashani, Meysam Shirzad, Mohammad Reza Memarzadeh, Ali Shamsizadeh, Ayat Kaeidi, Jalal Hassanshahi, Mahsa Hassanipour
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摘要

在伊朗,鸦片使用障碍(OUD)是阿片类药物使用率最高的疾病。本研究旨在探讨传统波斯化合物 Azaraghi Majoon(AM)对 OUD 大鼠模型的影响。AM 由 14 种草药和蜂蜜组合而成,使用高效液相色谱法对马钱子碱和布络辛进行了标准化,并通过灌胃给药。研究人员利用120只雄性小鼠研究了AM对鸦片戒断综合征表现和鸦片渴求的影响。纳洛酮诱发的戒断症状和条件性位置偏好(CPP)试验分别用于评估上述OUD的范围。采用改良的鸦片依赖时间表来评估生理依赖(持续八天)。在CPP范式中,不同组分别腹腔注射50毫克/毫升/千克的鸦片和灌胃50、100或150毫克/毫升/千克的AM。在CPP试验中,用AM(时间为50和150毫克/千克,频率为50、100和150毫克/千克)治疗鸦片成瘾动物可使其对药物区的偏好消失。此外,服用AM还能减少纳洛酮诱发鸦片戒断症状后出现的跳跃、腹泻、饲养和梳理的次数。在这项研究中,AM 可以改善大鼠鸦片使用障碍的生理和心理戒断症状,因此作者建议考虑进行临床试验,研究 AM 对 OUD 患者可能产生的有益影响。
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Effect of a traditional herbal formulation (Azaraghi Majoon) on opium use disorder in male rats

Opium Use Disorder (OUD) has the highest rate of opioid use disorder in Iran. The present study was designed to investigate the effect of Azaraghi Majoon (AM), a traditional Persian compound, on a rat model of OUD. AM was prepared from a combination of 14 herbs plus honey, standardized by strychnine and brucine using high-performance liquid chromatography, and administered by gavage. One hundred twenty male mice were used to investigate the effect of AM on the manifestations of opium withdrawal syndrome and craving for opium. Naloxone-precipitated withdrawal signs and conditioned place preference (CPP) test were used to assess the scopes mentioned above of OUD, respectively. A modified schedule of opium dependence was used to assess physical dependence (last for eight days). 50 mg/ml/kg intraperitoneal opium and 50, 100, or 150 mg/ml/kg gavaged AM in different groups were administered in the CPP paradigm. In the CPP test, treating opium-addicted animals with AM (50 and 150 mg/kg for time and 50, 100, and 150 mg/kg for frequency) resulted in the extinction of preference for drug compartments. Also, the administration of AM decreased the number of jumping, diarrhea, rearing, and grooming following naloxone-precipitated opium withdrawal signs. As AM could improve both physical and psychological withdrawal signs of opium use disorder in rats in this study, the authors suggest consideration of clinical trials to investigate possible beneficial effects of AM in OUD patients.

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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
期刊最新文献
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