{"title":"与阿片和大麻素受体相互作用的化合物的计算建模","authors":"Fatima Sapundzhi, T. Dzimbova","doi":"10.59957/jctm.v59.i4.2024.17","DOIUrl":null,"url":null,"abstract":"The present study was designed to investigate the structure-activity relationship between cannabinoid and opioid ligands with models of cannabinoid and opioid receptors. There are differences in the mechanisms of pain control for these two types of receptors, but targeting the creation of compounds that bind to both opioid and cannabinoid receptors lead to more effective solving of this problem. This will lead to the development of new and improved strategies to prevent opiate addiction and its consequences.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 46","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"COMPUTATIONAL MODELING OF COMPOUNDS THAT INTERACT WITH OPIOID AND CANNABINOID RECEPTORS\",\"authors\":\"Fatima Sapundzhi, T. Dzimbova\",\"doi\":\"10.59957/jctm.v59.i4.2024.17\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study was designed to investigate the structure-activity relationship between cannabinoid and opioid ligands with models of cannabinoid and opioid receptors. There are differences in the mechanisms of pain control for these two types of receptors, but targeting the creation of compounds that bind to both opioid and cannabinoid receptors lead to more effective solving of this problem. This will lead to the development of new and improved strategies to prevent opiate addiction and its consequences.\",\"PeriodicalId\":38363,\"journal\":{\"name\":\"Journal of Chemical Technology and Metallurgy\",\"volume\":\" 46\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Technology and Metallurgy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.59957/jctm.v59.i4.2024.17\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Technology and Metallurgy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.59957/jctm.v59.i4.2024.17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
COMPUTATIONAL MODELING OF COMPOUNDS THAT INTERACT WITH OPIOID AND CANNABINOID RECEPTORS
The present study was designed to investigate the structure-activity relationship between cannabinoid and opioid ligands with models of cannabinoid and opioid receptors. There are differences in the mechanisms of pain control for these two types of receptors, but targeting the creation of compounds that bind to both opioid and cannabinoid receptors lead to more effective solving of this problem. This will lead to the development of new and improved strategies to prevent opiate addiction and its consequences.
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