Association of Adiposity, Serum Vitamin D and Dietary Quality with Cardiometabolic Risk in Children aged 6 to 12 years: Findings from SEANUTS II Malaysia

Increased cardiometabolic risk among children is increasingly becoming a concern, with evidence indicating that obesity, diet, and serum 25-hydroxyvitamin D (25(OH)D) are associated with cardiometabolic risk. However, such studies among Malaysian children are scarce. Thus, this study explores the associations between adiposity, dietary quality, and 25(OH)D, with cardiometabolic risk factors among Malaysian children aged 4-12 years. Data of 4879 children (mean age: 8.2±2.3 years old, 53% females) from the South East Asian Nutrition Surveys (SEANUTS II) Malaysia, were analysed. Adiposity (percentage of body fat) was assessed with bioelectrical impedance technique. Dietary quality was assessed using 24-hour dietary recall and calculated as mean adequacy ratio (MAR). Vitamin D was assessed based on serum 25-hydroxyvitamin D (25(OH)D). Measurements of cardiometabolic risk factors included waist circumference, mean arterial pressure, fasting blood glucose, high-density lipoprotein (HDL), triglyceride, and high-sensitivity C-reactive protein, and cardiometabolic risk cluster score (siMS) was calculated. Overall, higher adiposity was positively associated with all cardiometabolic risk factors (WC, ß=0.907; 95%CI=0.865,0.948; MAP, ß=0.225; 95%CI=0.158, 0.292; HDL, ß =-0.011; 95%CI=-0.014, -0.009; Triglyceride, ß=0.012; 95%CI=0.009, 0.016; FBG, ß=0.006; 95%CI=0.002, 0.011) and siMS scores (ß=0.033; 95%CI=0.029, 0.037). Serum 25(OH)D was inversely associated with siMS scores (ß= -0.002; 95%CI= -0.004, -0.000008) and positively associated with HDL (ß=0.002; 95%CI=0.0001, 0.003). Our findings suggest that adiposity is a key determinant of adverse cardiometabolic risk factors in children, while serum 25(OH)D may be associated with overall cardiometabolic health. Interventions to reduce obesity are needed to mitigate the deleterious consequences of cardiometabolic dysregulation in children.