改良型腐植酸钠对完整小鼠腹膜巨噬细胞精氨酸平衡的影响

Pub Date : 2024-07-02 DOI:10.47056/0365-9615-2024-177-1-80-85

E. S. Trofimova, M. Zykova, M. G. Danilets, A. A. Ligacheva, E. Sherstoboev, N. S. Selivanova, L. A. Azarkina, A. Zhirkova, Yu. Zhang, I. V. Perminova, V. Zhdanov, M. Belousov

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引用次数: 0

摘要

通过 13 kDa 膜透析的银纳米粒子物质是在用对苯二酚和来自 PowHumus 褐煤的 2-hydroxynaphthoquinone 改性的腐殖质配体介质中合成的，由于抑制了 NO 合酶并显著激活了精氨酸酶，它们能特异性地增强腹腔巨噬细胞的 M2 特性，从而增强细胞的抗炎特性。腐殖酸盐的浓度虽小，但效果显著，它们不具有细胞毒性，也不含致热杂质。所研究的腐殖酸盐能够影响免疫反应的形成机制，是纠正炎症和再生的有效手段。

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Effect of Modified Forms of Sodium Humate PowHumus on the Balance of Arginine in Peritoneal Macrophages of Intact Mice.

Substances of silver nanoparticles dialyzed through a 13 kDa membrane, synthesized in a medium of humic ligands modified with hydroquinone and 2-hydroxynaphthoquinone from PowHumus brown coal, specifically enhance the M2 properties of peritoneal macrophages due to inhibition of NO synthase and significant activation of arginase, thus enhancing anti-inflammatory properties of cells. In small, but effective concentrations, they do not have cytotoxic properties and do not contain pyrogenic impurities. The studied humates are able to influence the mechanisms of immune response formation and are an effective means for correcting inflammation and regeneration.

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