治疗炎症诱发癌症的纳米疗法

Rajiv Kumar
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摘要

目的:纳米疗法正在作为治疗炎症诱发癌症的一种潜在解决方案进行探索。纳米疗法可增强先天性免疫细胞的免疫力,使其能够有效对抗肿瘤。这些细胞会分泌细胞因子等特定化学物质,使其能够快速复制并对未来的威胁做出反应,因此适合用于免疫疗法:纳米技术可以通过加强感染检测、预防和治疗,大大改善人类健康。纳米药物由亚微米级材料中的修复和成像化合物组成,旨在提供有效的治疗并限制健康身体部位的炎症。结合纳米技术和临床科学,纳米粒子适用于基因治疗,并已开发用于治疗各种疾病,包括癌症、心血管疾病、糖尿病、肺病和炎症性疾病:中性粒细胞及其后代,包括薄膜和细胞外载体,是增强生长治疗的重要药物运输工具。肿瘤微环境输入可改变肿瘤相关中性粒细胞(TANs),而中性粒细胞对肿瘤生长和愈合至关重要。人体肿瘤内的异质性对肿瘤的生长和愈合至关重要。纳米药物在靶向递送、降低毒性和提高疗效方面具有潜力。然而,由于缺乏对纳米材料、纳米药物和生物学之间相互作用的了解,临床相关性和有效性仍然不足。不同的生物环境会影响纳米制剂的动态生物特性,它们之间的相互作用会改变治疗功能或细胞吸收:纳米技术有望通过检测、预防和治疗感染来改善人类健康。纳米药物是临床科学与纳米技术的融合,利用亚微米级的传输材料进行治疗并减少污染。纳米粒子体积小、表面积与体积比高,有利于基因治疗。相关研究已在全球范围内开发出多种纳米医药产品。
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Nanotherapeutics to cure inflammation-induced cancer
Aims: Nanotherapeutics are being explored as a potential solution to treat inflammation-induced cancer. Nanotherapeutics enhance innate immune cells' immunity, enabling them to fight tumors effectively. These cells secrete specific chemicals like cytokines, allowing them to replicate quickly and respond to future threats, making them suitable for immunotherapy.Methods: Nanotechnology can significantly improve human health by enhancing infection detection, prevention, and treatment. Nanomedicines, composed of restorative and imaging compounds in submicrometer-sized materials, aim to deliver effective treatments and limit inflammation in healthy body areas. Combining nanotechnology and clinical sciences, nanoparticles are suitable for gene therapy and have been developed for treating various diseases, including cancer, cardiovascular, diabetes, pulmonary, and inflammatory diseases.Results: Neutrophils and their offspring, including films and extracellular vehicles, are crucial drug transporters for enhanced growth therapy. Tumor microenvironment inputs can modify tumor-associated neutrophils (TANs), which are essential for tumor growth and healing. Human tumor intratumor heterogeneity is crucial for tumor growth and healing. Nanomedicines have shown potential in targeted delivery, toxicity reduction, and therapeutic effectiveness enhancement. However, clinical relevance and efficacy remain inadequate due to a lack of understanding of the interaction between nanomaterials, nanomedicine, and biology. The diverse biological milieu impacts the dynamic bioidentity of nanoformulations, and their interactions can modify therapeutic function or cellular absorption.Conclusion: Nanotechnology holds great promise for improving human health by detecting, preventing, and treating infections. Nanomedicines, a fusion of clinical sciences and nanotechnology, use submicrometer-sized transporter materials for therapy delivery and reducing contamination. Nanoparticles' small size and high surface-to-volume ratio can benefit gene therapy. Research has led to a wide range of nanomedicine products globally.
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