用于联合递送多柔比星/pCRISPR 的先进掺 Ca MOF 纳米载体

IF 17.9 2区材料科学 Q1 Engineering Nano Materials Science Pub Date : 2025-10-01 Epub Date: 2024-07-03 DOI:10.1016/j.nanoms.2024.06.004

Bahareh Farasati Far , Mohammad Reza Naimi-Jamal , Sepideh Ahmadi , Navid Rabiee

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引用次数: 0

摘要

癌症治疗通常需要多模式的方法，如联合化疗和基因治疗。然而，诸如低疗效和脱靶效应等挑战阻碍了这些治疗的有效性。本研究提出利用掺钙金属有机骨架Cu2(BDC)2（DABCO）作为纳米载体平台，将多柔比星（DOX）与质粒CRISPR （pCRISPR）共递送，以提高抗癌效率。我们证明了ca掺杂的MOF纳米载体显著提高了肿瘤细胞对DOX和pCRISPR的摄取。DOX和pCRISPR与掺钙MOF纳米载体共递送导致细胞死亡显著增加，靶基因表达降低。

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Advanced Ca-doped MOF nanocarriers for Co-delivery of Doxorubicin/pCRISPR

Cancer treatment often requires a multimodal approach, such as combining chemotherapy and gene therapy. However, challenges such as low therapeutic efficacy and off-target effects hinder the effectiveness of these treatments. In this study, the use of calcium-doped metal-organic frameworks Cu₂(BDC)₂(DABCO) as a nanocarrier platform for the co-delivery of doxorubicin (DOX) and plasmid CRISPR (pCRISPR) proposed to enhance anticancer efficiency. We demonstrated that Ca-doped MOF nanocarriers significantly improved the uptake of DOX and pCRISPR by in cancer cells. The co-delivery of DOX and pCRISPR with Ca-doped MOF nanocarriers resulted in a significant rise in cell death and decreased targeted gene expression.

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来源期刊

Nano Materials Science Engineering-Mechanics of Materials

CiteScore

20.90

自引率

3.00%

发文量

294

审稿时长

9 weeks

期刊介绍： Nano Materials Science (NMS) is an international and interdisciplinary, open access, scholarly journal. NMS publishes peer-reviewed original articles and reviews on nanoscale material science and nanometer devices, with topics encompassing preparation and processing; high-throughput characterization; material performance evaluation and application of material characteristics such as the microstructure and properties of one-dimensional, two-dimensional, and three-dimensional nanostructured and nanofunctional materials; design, preparation, and processing techniques; and performance evaluation technology and nanometer device applications.