非糖尿病慢性肾病 3 期患者的肾阻指数和估计肾小球滤过率:一项横断面分析研究

Q3 Pharmacology, Toxicology and Pharmaceutics Pharmacognosy Journal Pub Date : 2024-07-01 DOI:10.5530/pj.2024.16.85
Patnaree Wongmanit, Kusuma Sriyakul, Parunkul Tungsukruthai, O. Supasyndh, Sucharat Tungsukruthai, Pratya Phetkate
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引用次数: 0

摘要

背景:肾阻力指数(RRI)和估计肾小球滤过率(eGFR)是慢性肾脏病(CKD)进展的预测指标。目的:评估泰国曼谷非糖尿病 CKD 3 期患者的 RRI 值、eGFRcr-cys 和肾脏生物标志物。方法:横断面分析对年龄在 35-85 岁之间的 CKD 3 期非糖尿病患者进行横断面分析。超声波用于评估双肾动脉的 RRI。患者还接受了血清和尿液 24 小时评估。结果显示在 61 名参与者(67.2% 为男性;平均年龄为 69.03 ± 12.59 岁)中,平均 eGFRcr-cys 为 41.63 ± 8.64 mL/min/1.73 m²,平均 RRI 为 0.65 ± 0.06。患者被分为三个 RRI 组:低 RRI 组(0.70,n=12)。高 RRI 组的平均 RRI 为 0.73 ± 0.05(P < 0.01)。高 RRI 组的右肾体积明显缩小(P<0.05),体重指数较低,平均为 22.49 ± 3.48。该组的 PP 值也显著增加(59.66 ± 13.84,P=0.04)。RRI 值的相关系数与年龄呈显著正相关(P<0.05),与体重指数呈显著负相关(P<0.05)。此外,eGFRcr-cys 与 UAGT 和 24hUP 呈显著负相关(p<0.05),与肾脏大小和尿 iNOS 呈显著正相关(p<0.01)。结论RRI 的增加与年龄、体重指数和 PP 成反比。较低的 eGFR 与导致 CKD 进展的因素相关。
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Renal Resistive Index and Estimated Glomerular Filtration Rate in Nondiabetic Chronic Kidney Disease Stage 3: A Cross-Sectional Analytical Study
Background: Renal resistive index (RRI) and estimated glomerular filtration rate (eGFR) are predictive markers for chronic kidney disease (CKD) progression. Aim: To evaluate RRI value, eGFRcr-cys and renal biomarker in nondiabetic patients with CKD stage 3 in Bangkok, Thailand. Methods: A cross-sectional analytical analysis was conducted involving nondiabetic patients with CKD stage 3, aged 35-85 years. Ultrasound was used to assess the RRI of arteries in both kidneys. Patients underwent assessments of serum and urine 24-hour. Results: Among the 61 participants (67.2% male; mean age 69.03 ± 12.59 years), the mean eGFRcr-cys was 41.63 ± 8.64 mL/min/1.73 m², and the mean RRI was 0.65 ± 0.06. Patients were categorized into three RRI groups: low (<0.65, n=35), intermediate (0.65-0.70, n=14), and high (>0.70, n=12). The high RRI group showed a mean RRI of 0.73 ± 0.05 (p < 0.01). Among those with high RRI group were significant decreased right kidney size (p<0.05) and they had a lower BMI, averaging 22.49 ± 3.48. An increase in PP (59.66 ± 13.84, p=0.04) was also significant in this group. The correlations coefficient of RRI value showed a significant positive correlation with age (p<0.05) and significant negative with BMI (p<0.05). In addition, eGFRcr-cys displayed a significant negative correlation with UAGT and 24hUP (p<0.05) and a significant while eGFRcr-cys positive correlation with both kidney size and urine iNOS(p<0.01). Conclusion: An increase in RRI is inversely linked to age, BMI, and PP. Lower eGFR is correlated with factors that cause CKD progression.
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来源期刊
Pharmacognosy Journal
Pharmacognosy Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
2.20
自引率
0.00%
发文量
151
期刊介绍: In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. Pharmacognosy Journal (Phcog J.) is one of the six journals published by Phcog.Net, Each issue covers different topics in natural product drug discovery, and also publishes manuscripts that describe pharmacognostic investigations, evaluation reports, methods, techniques and applications of all forms of medicinal plant research
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