体育锻炼(包括运动量和维持时间)与 2 型糖尿病患者罹患肝癌风险的关系

IF 9.5 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY JHEP Reports Pub Date : 2024-07-03 DOI:10.1016/j.jhepr.2024.101166
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引用次数: 0

摘要

背景& 目的我们研究了体力活动(PA)水平及其变化与 2 型糖尿病患者罹患肝细胞癌(HCC)风险的关联。共有 1,439,152 名患者被纳入分析。活动量水平分为不活跃(500 新陈代谢当量[MET]-min/周)、中等活跃(500-1,500 MET-min/周)和活跃(≥1,500 MET-min/周)。根据2009年至2011年期间PA的变化,将PA的变化分为持续不活跃PA、新近活跃PA、活跃PA戒断者和持续活跃PA。结果在中位5.2年的随访期间,22,686名患者患上了HCC。与不活跃组相比,中度活跃组(调整后危险比 [aHR] 0.96,95% CI 0.93-0.99)和活跃组(aHR 0.95,95% CI 0.91-0.99)患 HCC 的风险明显较低。结论:体育锻炼对糖尿病患者的肝细胞癌具有剂量反应性的预防作用。影响和意义:我们的研究调查了体育锻炼(PA)水平和变化对 2 型糖尿病患者肝细胞癌(HCC)风险的影响。体力活动对HCC具有剂量反应性的预防作用。持续积极参加体育锻炼组的患者患 HCC 的风险明显低于持续不参加体育锻炼组的患者,而新近参加体育锻炼的患者和放弃体育锻炼的患者患 HCC 的风险与持续不参加体育锻炼组的患者相似。我们的研究强调了保持规律的体育锻炼作为HCC预防策略的重要性。
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Association of physical activity, including amount and maintenance, with the risk of HCC among patients with type 2 diabetes

Background & Aims

We investigated the association of physical activity (PA) levels and changes with the risk of hepatocellular carcinoma (HCC) in patients with type 2 diabetes.

Methods

Patients with type 2 diabetes who had undergone health examinations in 2009 and 2011 were enrolled. In total, 1,439,152 patients were included in the analysis. The level of PA was classified as inactive (<500 metabolic equivalent task [MET]-min/week), moderately active (500-1,500 MET-min/week), and active (≥1,500 MET-min/week). Change in PA was categorized as persistently inactive PA, newly active PA, active PA quitter, and persistently active PA according to change of PA between 2009 and 2011.

Results

During a median of 5.2 years of follow-up, 22,686 patients developed HCC. Compared to the inactive group, the risk of HCC was significantly lower in the moderately active (adjusted hazard ratio [aHR] 0.96, 95% CI 0.93–0.99), and active (aHR 0.95, 95% CI 0.91–0.99) groups. The patients in the persistently active PA group had a significantly lower risk of HCC than those in the persistently inactive PA group (aHR 0.91, 95% CI 0.84–0.98).

Conclusions

Physical activity exhibited a dose-responsive preventive effect against HCC in patients with diabetes.

Impact and implications:

Our study investigated the impact of physical activity (PA) levels and changes on the risk of hepatocellular carcinoma (HCC) in patients with type 2 diabetes. PA was associated with a dose-responsive preventive effect against HCC. Patients in the persistently active PA group had a significantly lower risk of HCC than those in the persistently inactive PA group, while newly active patients and PA quitters had similar risks to the persistently inactive group. Our study highlighted the importance of maintaining regular PA as a preventive strategy against HCC.

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来源期刊
JHEP Reports
JHEP Reports GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
12.40
自引率
2.40%
发文量
161
审稿时长
36 days
期刊介绍: JHEP Reports is an open access journal that is affiliated with the European Association for the Study of the Liver (EASL). It serves as a companion journal to the highly respected Journal of Hepatology. The primary objective of JHEP Reports is to publish original papers and reviews that contribute to the advancement of knowledge in the field of liver diseases. The journal covers a wide range of topics, including basic, translational, and clinical research. It also focuses on global issues in hepatology, with particular emphasis on areas such as clinical trials, novel diagnostics, precision medicine and therapeutics, cancer research, cellular and molecular studies, artificial intelligence, microbiome research, epidemiology, and cutting-edge technologies. In summary, JHEP Reports is dedicated to promoting scientific discoveries and innovations in liver diseases through the publication of high-quality research papers and reviews covering various aspects of hepatology.
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Contents Editorial Board page Copyright and information Contents ALT levels, alcohol use, and metabolic risk factors have prognostic relevance for liver-related outcomes in the general population
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