M.D. Mitchell, C.F. Grzyboski, C.M. Dedhar, J.A. Hunter
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Arachidonic acid metabolism by lipoxygenase pathways in uterine and intrauterine tissues of pregnant sheep
The formation of arachidonate lipoxygenase products by uterine and intrauterine tissues of sheep in the last third of gestation has been evaluated. Maternal and fetal cotyledon, myometrium and fetal membrane exhibited evidence of arachidonate 5-, 12-, and 15- lipoxygenase activities. The major lipoxygenase product formed by fetal membrane and fetal cotyledon was leukotriene B4 (LTB4) whereas maternal cotyledon and myometrium produced mainly 12-hydroxyeicosatetraenoic acid (12-HETE). Arachidonate lipoxygenase products may play significant roles in the regulation of fetal and uteroplacental hemodynamics and it is speculated that the formation of leukotriene B4 predominantly by tissues of fetal origin may be of significance in the immunologic adaptations of pregnancy.
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