麦角酰二乙胺诱导草履虫的行为变化

IF 2.5 4区医学 Q3 NEUROSCIENCES Neuroscience Letters Pub Date : 2024-07-20 DOI:10.1016/j.neulet.2024.137903

Isis M. Ornelas , Beatriz de S. Carrilho , Matheus Antonio V. de C. Ventura , Ivan Domith , Christiane M. de V. Silveira , Vanessa F. dos Santos , João M. Delou , Francisco Moll , Henrique Marcelo G. Pereira , Magno Junqueira , Hugo Aguilaniu , Stevens Rehen

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引用次数: 0

摘要

麦角酰二乙胺（LSD）是一种人工合成的迷幻化合物，对精神疾病具有潜在的治疗价值。本研究旨在将 elegans（秀丽隐杆线虫）作为体内模型，研究 LSD 对运动行为的影响。我们的研究结果表明，草履虫会吸收迷幻剂，急性治疗会降低动物的速度，这与内源性血清素的作用类似。这种反应部分是由血清素能受体 SER-1 和 SER-4 介导的。我们的发现凸显了线虫作为迷幻药研究新实验模型的潜力。

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Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans

Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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