[坚果癌的发病机制和治疗研究进展]。

Q4 Medicine 中国肺癌杂志 Pub Date : 2024-06-20 DOI:10.3779/j.issn.1009-3419.2024.101.16

Jiaxin Du, Xinwei Zhang

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引用次数: 0

摘要

NUT 癌（睾丸癌核蛋白）是一种罕见的高侵袭性恶性肿瘤，最常见于中线器官和肺部。NUT 癌的特征性基因变化是 NUT 中癌家族成员 1（NUTM1）基因重排。本文将综述其最常见的融合形式--含溴多聚酶链蛋白 4（BRD4）-NUTM1 融合基因的致病机制，以及靶向药物的研发进展。.

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[Research Progress on Pathogenesis and Treatment of NUT Carcinoma].

NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family member 1 (NUTM1) gene. In this article, we will review the pathogenic mechanism of its most common fusion form, bromodomaincontaining protein 4 (BRD4)-NUTM1 fusion gene, and the progress in the research and development of targeting drugs. .

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来源期刊

中国肺癌杂志 Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

5131

审稿时长

14 weeks

期刊介绍： Chinese Journal of Lung Cancer(CJLC, pISSN 1009-3419, eISSN 1999-6187), a monthly Open Access journal, is hosted by Chinese Anti-Cancer Association, Chinese Antituberculosis Association, Tianjin Medical University General Hospital. CJLC was indexed in DOAJ, EMBASE/SCOPUS, Chemical Abstract(CA), CSA-Biological Science, HINARI, EBSCO-CINAHL,CABI Abstract, Global Health, CNKI, etc. Editor-in-Chief: Professor Qinghua ZHOU.