解密分子工具包:海洋软体动物贝壳生物矿化的调控要素。

IF 3.5 1区 生物学 Q1 ZOOLOGY Integrative zoology Pub Date : 2024-07-18 DOI:10.1111/1749-4877.12876
Zhuoqing Li, Meijie Yang, Cong Zhou, Pu Shi, Pengpeng Hu, Bin Liang, Qingtian Jiang, Lili Zhang, Xiaoyan Liu, Changping Lai, Tao Zhang, Hao Song
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引用次数: 0

摘要

海洋软体动物复杂的贝壳生物矿化过程受复杂的调控要素相互作用的支配,其中包括分泌体、转运体和非编码 RNA。这篇综述深入探讨了了解这些调控机制的最新进展,强调了它们在阐明软体动物贝壳生物矿化过程的功能和进化动态方面的重要意义。在这一错综复杂的协调过程中,具有不同功能域的分泌物组起着核心作用,它们有选择性地输出到外层空间,直接调节晶体生长和形态。转运体对于钙化过程中的底物运输和维持细胞平衡至关重要。除蛋白质和转运体外,非编码 RNA 分子也是影响贝壳生物矿化不可或缺的组成部分。本综述强调了这些遗传因子在分子水平上发挥的不可忽视的作用。为了理解软体动物生物矿化的复杂性,我们探讨了调控元件(主要是分泌组)的起源和进化历史。有些基因元件是最近才进化出来的,而有些则是古老的基因,它们被共同纳入了生物矿化工具包。这些元素通过快速进化的重复低复杂性结构域和结构域增益/丢失/重排,经历了结构和功能的进化,最终形成了一套独特的分泌组,其特点是既有保守的特征,又有进化创新。这篇全面的综述从分子和遗传学层面加深了我们对软体动物生物矿化的了解。
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Deciphering the molecular toolkit: regulatory elements governing shell biomineralization in marine molluscs.

The intricate process of shell biomineralization in marine molluscs is governed by a complex interplay of regulatory elements, encompassing secretomes, transporters, and noncoding RNA. This review delves into recent advancements in understanding these regulatory mechanisms, emphasizing their significance in elucidating the functions and evolutionary dynamics of the molluscan shell biomineralization process. Central to this intricate orchestration are secretomes with diverse functional domains, selectively exported to the extrapallial space, which directly regulate crystal growth and morphology. Transporters are crucial for substrate transportation in the calcification and maintenance of cellular homeostasis. Beyond proteins and transporters, noncoding RNA molecules are integral components influencing shell biomineralization. This review underscores the nonnegligible roles played by these genetic elements at the molecular level. To comprehend the complexity of biomineralization in mollusc, we explore the origin and evolutionary history of regulatory elements, primarily secretomes. While some elements have recently evolved, others are ancient genes that have been co-opted into the biomineralization toolkit. These elements undergo structural and functional evolution through rapidly evolving repetitive low-complexity domains and domain gain/loss/rearrangements, ultimately shaping a distinctive set of secretomes characterized by both conserved features and evolutionary innovations. This comprehensive review enhances our understanding of molluscan biomineralization at the molecular and genetic levels.

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来源期刊
CiteScore
6.40
自引率
12.10%
发文量
81
审稿时长
>12 weeks
期刊介绍: The official journal of the International Society of Zoological Sciences focuses on zoology as an integrative discipline encompassing all aspects of animal life. It presents a broader perspective of many levels of zoological inquiry, both spatial and temporal, and encourages cooperation between zoology and other disciplines including, but not limited to, physics, computer science, social science, ethics, teaching, paleontology, molecular biology, physiology, behavior, ecology and the built environment. It also looks at the animal-human interaction through exploring animal-plant interactions, microbe/pathogen effects and global changes on the environment and human society. Integrative topics of greatest interest to INZ include: (1) Animals & climate change (2) Animals & pollution (3) Animals & infectious diseases (4) Animals & biological invasions (5) Animal-plant interactions (6) Zoogeography & paleontology (7) Neurons, genes & behavior (8) Molecular ecology & evolution (9) Physiological adaptations
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