儿童肠道病毒和帕累托病毒感染的临床表现和处理:澳大利亚地区单中心研究。

IF 1.9 4区 医学 Q2 NURSING Australian Journal of Rural Health Pub Date : 2024-07-19 DOI:10.1111/ajr.13160
Tharmarajah Sorubarajan MBBS (Sri Lanka), MD (Sri Lanka), DCH (Sri Lanka), DCH (Sydney), FRACP (Australia), Sivapriyan Sorubarajan
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引用次数: 0

摘要

研究目的本研究旨在分析儿童感染肠道病毒(EV)和/或人类帕累托病毒(HPeV)后的临床表现,以及澳大利亚一家地区医院对此类病例的处理情况:方法:回顾性研究,审查医疗记录:环境:澳大利亚地区的一家医院:自 2017 年 1 月 1 日起的 5 年间,所有 18 岁以下确诊 EV 和/或 HPeV 感染的儿童。排除了临床症状不明显的EV/HPeV分离病例:收集的数据包括人口统计学数据、出现的体征和症状、EV/HPeV分离标本、并发病原体、C反应蛋白(CRP)峰值、抗生素治疗、出院诊断和出院后随访:共有 27 名患者符合纳入标准;81.5% 的患者年龄小于 3 个月,中位数为 2 个月(四分位数间距为 1-3 个月);74.1% 为男性。最常见的临床特征是发烧≥38°C和烦躁/嗜睡/高声哭闹。29.6%的患者同时检测到病原体,77.8%的病例CRP≤10 mg/L。除两名患儿外,其他患儿在等待聚合酶链反应结果期间均接受了抗生素治疗。最常见的出院诊断是脑膜炎。74.1%的患儿接受了后续治疗:结论:EV 和 HPeV 应被视为 3 个月以下儿童发烧和烦躁/嗜睡/高声哭闹的可能病因。
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Clinical presentation and management of enterovirus and parechovirus infection in children: A single-centre study in regional Australia

Objective

This study aims to analyse the clinical presentation caused by enterovirus (EV) and/or human parechovirus (HPeV) infection in children, as well as the management of such cases admitted to a regional hospital in Australia.

Methods

Retrospective study reviewing medical records.

Setting

Single hospital in regional Australia.

Participants

All children under 18 years admitted over the 5-year period beginning from 1 January 2017 with confirmed EV and/or HPeV infection. Cases with clinically insignificant EV/HPeV isolation were excluded.

Main Outcome Measures

Data collected included demographic data, signs and symptoms present, specimens of EV/HPeV isolation, co-occurring pathogens, peak C-reactive protein (CRP), antibiotic therapy, discharge diagnosis and follow-up after discharge.

Results

Overall, 27 patients fulfilled the inclusion criteria; 81.5% of the patients were ≤3 months of age with a median of 2 months (interquartile range 1–3); 74.1% were males. The most common clinical features were a fever ≥38°C and irritability/lethargy/high-pitched cry. 29.6% of the patients had co-occurring pathogens detected, and a CRP ≤10 mg/L was observed in 77.8% of cases. All but two children were treated with antibiotics while awaiting polymerase chain reaction results. The most common discharge diagnosis was meningitis. In all, 74.1% of the children attended follow-up appointments.

Conclusions

EV and HPeV should be considered as a possible aetiology of fever and irritability/lethargy/high-pitched cry in children under 3 months.

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来源期刊
Australian Journal of Rural Health
Australian Journal of Rural Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.30
自引率
16.70%
发文量
122
审稿时长
12 months
期刊介绍: The Australian Journal of Rural Health publishes articles in the field of rural health. It facilitates the formation of interdisciplinary networks, so that rural health professionals can form a cohesive group and work together for the advancement of rural practice, in all health disciplines. The Journal aims to establish a national and international reputation for the quality of its scholarly discourse and its value to rural health professionals. All articles, unless otherwise identified, are peer reviewed by at least two researchers expert in the field of the submitted paper.
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