内源性和外源性激素对年轻女性下肢运动和 III/IV 组激活的心血管反应的影响。

IF 2.2 3区 医学 Q3 PHYSIOLOGY American journal of physiology. Regulatory, integrative and comparative physiology Pub Date : 2024-10-01 Epub Date: 2024-07-22 DOI:10.1152/ajpregu.00017.2024
Ninitha Asirvatham-Jeyaraj, Miguel Anselmo, Daniel P Chantigian, Mia Larson, Emma J Lee, Manda L Keller-Ross
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引用次数: 0

摘要

使用口服避孕药(OC)会增加女性的静息血压(BP),并在上肢运动时导致 III/IV 组传入的更大激活。然而,OC 使用者在下肢运动时是否会出现夸张的血压反应还不得而知。我们试图阐明年轻健康女性在卵泡早期和晚期进行下肢运动时,由 III/IV 组传入活动介导的血压和心率反应。未服用 OCs 的女性(NOC:n=8;年龄:25±4 岁)和服用 OCs 的女性(OC:n=10;年龄:23±2 岁)完成了连续伸膝/屈膝被动拉伸(机械反射)和收缩压下袖带闭塞的骑自行车运动(运动加压反射),随后进行了两分钟的运动后循环闭塞(PECO)(代谢反射)。数据收集分两次进行:一次在月经周期的卵泡早期(第 1-4 天),另一次在卵泡晚期(第 10-14 天)(NOC),或在服用安慰剂和活性药片阶段(OC)。NOC 和 OC 参与者的静息平均动脉血压和心率在不同阶段没有差异(P>0.05)。两组患者对代谢反射、机械反射和集体运动加压反射激活的血流动力学反应在不同阶段没有差异(P>0.05)。总之,尽管众所周知 OC 会增加静息时的血压,但我们的研究结果表明,在年轻、健康的女性中,无论是否有 III/IV 组传入激活,内源性或外源性(OC)性激素都不会调节下肢肌肉大运动时的血压。
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Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.

Oral contraceptive (OC) use can increase resting blood pressure (BP) in females as well as contribute to greater activation of group III/IV afferents during upper body exercise. It is unknown, however, whether an exaggerated BP response occurs during lower limb exercise in OC users. We sought to elucidate the group III/IV afferent activity-mediated BP and heart rate responses while performing lower extremity tasks during early and late follicular phases in young, healthy females. Females not taking OCs (NOC: n = 8; age: 25 ± 4 yr) and those taking OCs (OC: n = 10; age: 23 ± 2 yr) completed a continuous knee extension/flexion passive stretch (mechanoreflex) and cycling exercise with subsystolic cuff occlusion (exercise pressor reflex), which was followed by a 2-min postexercise circulatory occlusion (PECO) (metaboreflex). Data collection occurred on two occasions: once during the early follicular phase (days 1-4) and once during the late follicular phase (days 10-14) of their menstrual cycle (NOC) or during the placebo and active pill phases (OC). Resting mean arterial BP and heart rate were not different between phases in NOC and OC participants (P > 0.05). Hemodynamic responses to metaboreflex, mechanoreflex, and collective exercise pressor reflex activation were not different between phases in both groups (P > 0.05). In conclusion, although OCs are known to increase BP at rest, our findings indicate that neither endogenous nor exogenous (OC) sex hormones modulate BP during large, lower limb muscle exercise with or without group III/IV afferent activation in young, healthy females.NEW & NOTEWORTHY Sex differences in the cardiovascular response to exercise have been demonstrated and may be dependent on sex hormone levels. Furthermore, oral contraceptives (OCs) have been shown to exaggerate the blood pressure response to upper extremity exercise. The results of this study indicate that neither endogenous nor exogenous (OC) sex hormones modulate BP during lower extremity dynamic exercise or with group III/IV afferent activation in young, healthy females.

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来源期刊
CiteScore
5.30
自引率
3.60%
发文量
145
审稿时长
2 months
期刊介绍: The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
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