基于三价蛋白的泛冠状病毒疫苗可激发针对冠状病毒假病毒的交叉中和抗体。

IF 6.9 1区医学 Q1 IMMUNOLOGY NPJ Vaccines Pub Date : 2024-07-22 DOI:10.1038/s41541-024-00924-x

Syamala Rani Thimmiraju, Rakesh Adhikari, JeAnna R Redd, Maria Jose Villar, Jungsoon Lee, Zhuyun Liu, Yi-Lin Chen, Suman Sharma, Amandeep Kaur, Nestor L Uzcategui, Shannon E Ronca, Wen-Hsiang Chen, Jason T Kimata, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Jeroen Pollet

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摘要

开发广谱冠状病毒疫苗对于应对未来的呼吸道病毒大流行至关重要。我们用明矾和 CpG55.2 配制了 SARS-CoV、MERS-CoV 和 SARS-CoV-2 XBB.1.5 的受体结合域，证明了三价亚单位疫苗的广泛中和作用。接种疫苗的小鼠产生了针对所有三种人类贝他克罗病毒和目前蝙蝠独有的其他病毒的交叉中和抗体，这表明在共同配制过程中单个抗原的表位得到了保留，并有可能扩大表位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses.

The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.