内脏利什曼病中国西北部一例通过元基因组下一代测序确认的病例

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES Infection and Drug Resistance Pub Date : 2024-07-18 DOI:10.2147/idr.s472172

Ente Li, Qingfeng Zhu, Ziman Lv, Songsong Xie, Chunju Zhang, Wei Li, Ligu Mi, Quan Liu, Yuanzhi Wang, Xiaobo Lu

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摘要

摘要：内脏利什曼病（VL），又称卡拉-扎尔病。其特征是长期间歇性发热、贫血、脾脏肿大、肝脏肿大和皮肤变黑。VL主要流行于巴西、东非和印度等地区。然而，位于中国西北部的新疆北部被认为是 VL 的低发地区，这也导致其成为一种被忽视的传染病。在本报告中，我们介绍了一例通过元基因组下一代测序（mNGS）确诊的由唐诺瓦利什曼原虫引起的 VL 病例。该病例强调了 mNGS 的诊断价值，尤其是在 VL 发病率较低的地区。关键词：内脏利什曼病内脏利什曼病唐氏利什曼原虫元基因组新一代测序中国西北地区

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Visceral Leishmaniasis: A Case Confirmed by Metagenomic Next-Generation Sequencing from Northwestern China

Abstract: Visceral leishmaniasis (VL), also known as kala-azar. It is characterized by prolonged intermittent fever, anemia, splenomegaly, hepatomegaly, and skin darkening. VL is primarily endemic in regions, such as Brazil, East Africa, and India. However, Northern Xinjiang, which is located in northwestern China, is considered a low-incidence area for VL, contributing to its status as a neglected infectious disease. In this report, we present a case of VL caused by Leishmania donovani that was diagnosed using metagenomic next-generation sequencing (mNGS). This case underscores the diagnostic value of mNGS, particularly in regions with low incidence of VL.

Keywords: Visceral leishmaniasis, Leishmania donovani, metagenomic next-generation sequencing, northwestern China

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.