连接赖特-费舍模型和莫兰模型

Arthur Alexandre, Alia Abbara, Cecilia Fruet, Claude Loverdo, Anne-Florence Bitbol
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引用次数: 0

摘要

赖特-费舍模型和莫兰模型都被广泛应用于种群遗传学。它们描述了一个具有固定规模的混合良好种群中类群频率的时间演化。我们提出了一个简单而实用的模型,它是赖特-费舍模型和莫兰模型的桥梁。我们假定,在每个离散的时间步中,种群的固定部分会被更新。在这个模型中,我们确定了扩散近似中突变体的固定概率以及有效种群规模。我们对模型进行了归纳,首先考虑了更新部分或个体生命周期的波动,然后加入了对生命周期和生殖适应性的选择。
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Bridging Wright-Fisher and Moran models
The Wright-Fisher model and the Moran model are both widely used in population genetics. They describe the time evolution of the frequency of an allele in a well-mixed population with fixed size. We propose a simple and tractable model which bridges the Wright-Fisher and the Moran descriptions. We assume that a fixed fraction of the population is updated at each discrete time step. In this model, we determine the fixation probability of a mutant in the diffusion approximation, as well as the effective population size. We generalize our model, first by taking into account fluctuating updated fractions or individual lifetimes, and then by incorporating selection on the lifetime as well as on the reproductive fitness.
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