{"title":"利用磷脂作为安立生坦固体分散体的两性载体：配方与评估","authors":"Subhash Deshmane, Kamlesh Kendre, Snehal Deshmane, Shirish Jain, Atish Sawant, Himanshu Solanki","doi":"10.1080/01932691.2024.2381020","DOIUrl":null,"url":null,"abstract":"The partial water solubility of ambrisentan poses a challenge to its oral administration despite being the second oral endothelin A-receptor antagonist approved in the United States. In this study,...","PeriodicalId":15574,"journal":{"name":"Journal of Dispersion Science and Technology","volume":"30 1","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Utilizing phospholipid as an amphiphilic carrier for solid dispersion of ambrisentan: formulation and evaluation\",\"authors\":\"Subhash Deshmane, Kamlesh Kendre, Snehal Deshmane, Shirish Jain, Atish Sawant, Himanshu Solanki\",\"doi\":\"10.1080/01932691.2024.2381020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The partial water solubility of ambrisentan poses a challenge to its oral administration despite being the second oral endothelin A-receptor antagonist approved in the United States. In this study,...\",\"PeriodicalId\":15574,\"journal\":{\"name\":\"Journal of Dispersion Science and Technology\",\"volume\":\"30 1\",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Dispersion Science and Technology\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/01932691.2024.2381020\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dispersion Science and Technology","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/01932691.2024.2381020","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
摘要
尽管安利生坦是美国批准的第二种口服内皮素 A 受体拮抗剂，但其部分水溶性给口服带来了挑战。在这项研究中，...
Utilizing phospholipid as an amphiphilic carrier for solid dispersion of ambrisentan: formulation and evaluation
The partial water solubility of ambrisentan poses a challenge to its oral administration despite being the second oral endothelin A-receptor antagonist approved in the United States. In this study,...
期刊介绍：
Journal of Dispersion Science and Technology is an international journal covering fundamental and applied aspects of dispersions, emulsions, vesicles, microemulsions, liquid crystals, particle suspensions and sol-gel processes. Fundamental areas that are covered include new surfactants, polymers and indigenous stabilizers; surfactant and polymer association as well as phase equilibria in systems water and oil; surfactant and polymer films, monolayers and interfacial films; adsorption and desorption onto solid surfaces; stability and destabilization of dispersions, emulsions and particle suspensions; collodal templates and sol-gel processing. Industrial applications cover chemicals, crude oils, food, pharmaceuticals, agriculture, nanotechnology, and soft condensed materials.
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