记忆门诊队列中的白天嗜睡、呼吸暂停、神经影像学相关性和皮质醇失调

Charlotte Sørensen, I. Kåreholt, G. Kalpouzos, C. T. Udeh-Momoh, J. Holleman, M. Aspö, G. Hagman, G. Spulber, M. Kivipelto, A. Solomon, S. Sindi
{"title":"记忆门诊队列中的白天嗜睡、呼吸暂停、神经影像学相关性和皮质醇失调","authors":"Charlotte Sørensen, I. Kåreholt, G. Kalpouzos, C. T. Udeh-Momoh, J. Holleman, M. Aspö, G. Hagman, G. Spulber, M. Kivipelto, A. Solomon, S. Sindi","doi":"10.14283/jpad.2024.145","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Sleep disturbances as well as cortisol hypersecretion are increasingly acknowledged as risk factors for Alzheimer’s disease (AD). However, the mechanisms underlying the association, and the interplay with cortisol abnormalities, remain unclear.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>This study aims to identify how self-reported sleep disturbances are associated with structural brain measures and diurnal cortisol dysregulation among memory clinic patients.</p><h3 data-test=\"abstract-sub-heading\">Design</h3><p>A cross-sectional study performed at Karolinska University Hospital Memory Clinic, Sweden.</p><h3 data-test=\"abstract-sub-heading\">Participants</h3><p>The study was based on 146 memory clinic patients diagnosed with either subjective cognitive impairment or mild cognitive impairment.</p><h3 data-test=\"abstract-sub-heading\">Measurements</h3><p>Self-reported sleep was measured using the Karolinska Sleep Questionnaire. MRI or CT was used to quantify structural brain measures using four visual rating scales (Scheltens, Pasquier, Koedam, and Fazekas scales), and salivary cortisol was sampled to measure diurnal cortisol patterns through measures of cortisol immediately after awakening, cortisol awakening response, bedtime cortisol, total cortisol from awakening to bedtime, and the AM/PM cortisol ratio.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Increased sleep apnea index (OR=1.20, 95% CI=1.04:1.39, p=0.015) was associated with greater odds of posterior brain atrophy, measured by the Koedam visual rating scale, and reduced awakening Cortisol (β=−0.03, 95% CI=− 0.07:0.00, p=0.045). Increased daytime sleepiness was associated with both reduced awakening cortisol (β=−0.03, 95% CI=−0.06:0.00, p=0.025) and a reduced AM/PM cortisol ratio (β=−0.04, CI=−0.08:−0.01, p= 0.021).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>In a memory clinic cohort self-reported sleep disturbances are associated with both worse structural brain tissue integrity and altered diurnal cortisol profiles. These findings may add insights into possible mechanisms behind sleep disturbances in aging with subjective and cognitive impairment.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Daytime Sleepiness, Apnea, Neuroimaging Correlates and Cortisol Dysregulation in a Memory Clinic Cohort\",\"authors\":\"Charlotte Sørensen, I. Kåreholt, G. Kalpouzos, C. T. Udeh-Momoh, J. Holleman, M. Aspö, G. Hagman, G. Spulber, M. Kivipelto, A. Solomon, S. Sindi\",\"doi\":\"10.14283/jpad.2024.145\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Sleep disturbances as well as cortisol hypersecretion are increasingly acknowledged as risk factors for Alzheimer’s disease (AD). However, the mechanisms underlying the association, and the interplay with cortisol abnormalities, remain unclear.</p><h3 data-test=\\\"abstract-sub-heading\\\">Objectives</h3><p>This study aims to identify how self-reported sleep disturbances are associated with structural brain measures and diurnal cortisol dysregulation among memory clinic patients.</p><h3 data-test=\\\"abstract-sub-heading\\\">Design</h3><p>A cross-sectional study performed at Karolinska University Hospital Memory Clinic, Sweden.</p><h3 data-test=\\\"abstract-sub-heading\\\">Participants</h3><p>The study was based on 146 memory clinic patients diagnosed with either subjective cognitive impairment or mild cognitive impairment.</p><h3 data-test=\\\"abstract-sub-heading\\\">Measurements</h3><p>Self-reported sleep was measured using the Karolinska Sleep Questionnaire. MRI or CT was used to quantify structural brain measures using four visual rating scales (Scheltens, Pasquier, Koedam, and Fazekas scales), and salivary cortisol was sampled to measure diurnal cortisol patterns through measures of cortisol immediately after awakening, cortisol awakening response, bedtime cortisol, total cortisol from awakening to bedtime, and the AM/PM cortisol ratio.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>Increased sleep apnea index (OR=1.20, 95% CI=1.04:1.39, p=0.015) was associated with greater odds of posterior brain atrophy, measured by the Koedam visual rating scale, and reduced awakening Cortisol (β=−0.03, 95% CI=− 0.07:0.00, p=0.045). Increased daytime sleepiness was associated with both reduced awakening cortisol (β=−0.03, 95% CI=−0.06:0.00, p=0.025) and a reduced AM/PM cortisol ratio (β=−0.04, CI=−0.08:−0.01, p= 0.021).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>In a memory clinic cohort self-reported sleep disturbances are associated with both worse structural brain tissue integrity and altered diurnal cortisol profiles. These findings may add insights into possible mechanisms behind sleep disturbances in aging with subjective and cognitive impairment.</p>\",\"PeriodicalId\":22711,\"journal\":{\"name\":\"The Journal of Prevention of Alzheimer's Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Prevention of Alzheimer's Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14283/jpad.2024.145\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BUSINESS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Prevention of Alzheimer's Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14283/jpad.2024.145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BUSINESS","Score":null,"Total":0}
引用次数: 0

摘要

背景睡眠障碍和皮质醇分泌过多越来越被认为是阿尔茨海默病(AD)的风险因素。本研究旨在确定记忆门诊患者自我报告的睡眠障碍与大脑结构测量和皮质醇昼夜失调之间的关系。设计瑞典卡罗林斯卡大学医院记忆门诊进行了一项横断面研究。参与者本研究基于 146 名被诊断为主观认知障碍或轻度认知障碍的记忆门诊患者。采用核磁共振成像或 CT,使用四种视觉评分量表(Scheltens、Pasquier、Koedam 和 Fazekas 量表)对大脑结构进行量化测量,并采集唾液皮质醇样本,通过测量皮质醇唤醒后的立即皮质醇、皮质醇唤醒反应、睡前皮质醇、从唤醒到睡前的皮质醇总量以及上午/下午皮质醇比率来测量昼夜皮质醇模式。结果睡眠呼吸暂停指数增加(OR=1.20,95% CI=1.04:1.39,p=0.015)与科达姆视觉评分量表测量的后脑萎缩几率增加和觉醒皮质醇减少(β=-0.03,95% CI=-0.07:0.00,p=0.045)有关。白天嗜睡增加与觉醒皮质醇降低(β=-0.03,95% CI=-0.06:0.00,p=0.025)和上午/下午皮质醇比率降低(β=-0.04,CI=-0.08:-0.01,p=0.021)有关。这些发现可能有助于人们深入了解主观和认知功能受损的老年患者睡眠障碍背后的可能机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Daytime Sleepiness, Apnea, Neuroimaging Correlates and Cortisol Dysregulation in a Memory Clinic Cohort

Background

Sleep disturbances as well as cortisol hypersecretion are increasingly acknowledged as risk factors for Alzheimer’s disease (AD). However, the mechanisms underlying the association, and the interplay with cortisol abnormalities, remain unclear.

Objectives

This study aims to identify how self-reported sleep disturbances are associated with structural brain measures and diurnal cortisol dysregulation among memory clinic patients.

Design

A cross-sectional study performed at Karolinska University Hospital Memory Clinic, Sweden.

Participants

The study was based on 146 memory clinic patients diagnosed with either subjective cognitive impairment or mild cognitive impairment.

Measurements

Self-reported sleep was measured using the Karolinska Sleep Questionnaire. MRI or CT was used to quantify structural brain measures using four visual rating scales (Scheltens, Pasquier, Koedam, and Fazekas scales), and salivary cortisol was sampled to measure diurnal cortisol patterns through measures of cortisol immediately after awakening, cortisol awakening response, bedtime cortisol, total cortisol from awakening to bedtime, and the AM/PM cortisol ratio.

Results

Increased sleep apnea index (OR=1.20, 95% CI=1.04:1.39, p=0.015) was associated with greater odds of posterior brain atrophy, measured by the Koedam visual rating scale, and reduced awakening Cortisol (β=−0.03, 95% CI=− 0.07:0.00, p=0.045). Increased daytime sleepiness was associated with both reduced awakening cortisol (β=−0.03, 95% CI=−0.06:0.00, p=0.025) and a reduced AM/PM cortisol ratio (β=−0.04, CI=−0.08:−0.01, p= 0.021).

Conclusion

In a memory clinic cohort self-reported sleep disturbances are associated with both worse structural brain tissue integrity and altered diurnal cortisol profiles. These findings may add insights into possible mechanisms behind sleep disturbances in aging with subjective and cognitive impairment.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
期刊最新文献
Association between Cognitive Reserve Indicator and Chronic Disease-Free Survival: A Large Community-Based Longitudinal Study Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer’s Disease Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer’s Disease Development and Validation the Mobile Toolbox (MTB) Spelling Test Correlates of Subjective Cognitive Decline in Black American Men
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1