{"title":"动物体内镉暴露与甲状腺功能的关系:系统回顾","authors":"Maryam Nazarian, Pouria Mohammadparast Tabas, Mohammad Sadra Harifi-Mood, Hamed Aramjoo, Ahmad Bavali-Gazik, Amirhossein Saberi, Yasaman Peyghambari, Peyman Mohammadparast-Tabas, Amirhosein Anghoshtary, Saeed Samarghandian, Tahereh Farkhondeh","doi":"10.2174/0115665240288797240704134652","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several studies have indicated an association between cadmium (Cd) exposure and the induction of thyroid dysfunction in animal models. Objective and Aims: There are inconsistent findings on the effect of Cd on the thyroid gland. Therefore, this systematic study was designed to determine the association between changes in thyroid function markers and Cd exposure in animals.</p><p><strong>Method: </strong>The search was performed on Scopus, PubMed, Web of Science and databases, and Google Scholar until May 2023. Studies on the relationship between Cd exposure and fish's thyroid function were conducted on rodents and fish.</p><p><strong>Results: </strong>In total, 171 articles were obtained from the main databases using the search strategy mentioned in this study. Finally, 24 articles were selected according to our inclusion criteria for systematic studies. The findings indicated an increase/decrease or no change in triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) levels in rodents, fish, and animals exposed to Cd.</p><p><strong>Conclusion: </strong>Our findings indicated an association between Cd exposure and thyroid dysfunction in rodents, fish, and other animals. However, the association between urinary and blood Cd levels and thyroid function remains unclear in humans because of controversial findings and a lack of strong mechanistic evidence. We perform large cohort human studies to the answer to this question.</p>","PeriodicalId":10873,"journal":{"name":"Current molecular medicine","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review.\",\"authors\":\"Maryam Nazarian, Pouria Mohammadparast Tabas, Mohammad Sadra Harifi-Mood, Hamed Aramjoo, Ahmad Bavali-Gazik, Amirhossein Saberi, Yasaman Peyghambari, Peyman Mohammadparast-Tabas, Amirhosein Anghoshtary, Saeed Samarghandian, Tahereh Farkhondeh\",\"doi\":\"10.2174/0115665240288797240704134652\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Several studies have indicated an association between cadmium (Cd) exposure and the induction of thyroid dysfunction in animal models. 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引用次数: 0
摘要
背景:多项研究表明,在动物模型中,镉(Cd)暴露与甲状腺功能障碍的诱导存在关联。目的和宗旨:关于镉对甲状腺的影响,研究结果并不一致。因此,本系统研究旨在确定动物甲状腺功能指标的变化与镉暴露之间的关联:方法:在Scopus、PubMed、Web of Science和数据库以及Google Scholar上进行搜索,搜索时间截止到2023年5月。有关镉暴露与鱼类甲状腺功能之间关系的研究以啮齿动物和鱼类为对象:采用本研究中提到的检索策略,从主要数据库中共获得 171 篇文章。最后,根据系统研究的纳入标准选出了 24 篇文章。研究结果表明,啮齿动物、鱼类和接触过镉的动物体内的三碘甲状腺原氨酸(T3)、甲状腺素(T4)和促甲状腺激素(TSH)水平有升高/降低或无变化:我们的研究结果表明,啮齿动物、鱼类和其他动物体内的镉暴露与甲状腺功能障碍之间存在关联。然而,由于研究结果存在争议且缺乏有力的机理证据,尿液和血液中的镉水平与人类甲状腺功能之间的关系仍不明确。我们对人类进行了大规模的队列研究,以寻找这一问题的答案。
The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review.
Background: Several studies have indicated an association between cadmium (Cd) exposure and the induction of thyroid dysfunction in animal models. Objective and Aims: There are inconsistent findings on the effect of Cd on the thyroid gland. Therefore, this systematic study was designed to determine the association between changes in thyroid function markers and Cd exposure in animals.
Method: The search was performed on Scopus, PubMed, Web of Science and databases, and Google Scholar until May 2023. Studies on the relationship between Cd exposure and fish's thyroid function were conducted on rodents and fish.
Results: In total, 171 articles were obtained from the main databases using the search strategy mentioned in this study. Finally, 24 articles were selected according to our inclusion criteria for systematic studies. The findings indicated an increase/decrease or no change in triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) levels in rodents, fish, and animals exposed to Cd.
Conclusion: Our findings indicated an association between Cd exposure and thyroid dysfunction in rodents, fish, and other animals. However, the association between urinary and blood Cd levels and thyroid function remains unclear in humans because of controversial findings and a lack of strong mechanistic evidence. We perform large cohort human studies to the answer to this question.
期刊介绍:
Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.