分析安非他酮和右美沙芬的组合作为治疗重度抑郁障碍的一种选择。

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Expert Review of Neurotherapeutics Pub Date : 2024-09-01 Epub Date: 2024-07-22 DOI:10.1080/14737175.2024.2374024
Joseph Blanco, Pamela Quimbaya, Manuel Mena, Seetal Dodd, Rosa-Helena Bustos
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引用次数: 0

摘要

简介重度抑郁症(MDD)是一种常见的精神疾病,以悲伤、绝望和失神为特征。目前已有多种疗法,但疗效有限。氢溴酸右美沙芬联合盐酸安非他酮(Auvelity®)是最近获得批准的治疗成人抑郁症的替代药物:本综述概述了重度抑郁症的神经生物学,并深入研究了右美沙芬联合盐酸安非他酮治疗成人患者的药理学、疗效、安全性和耐受性。该综述基于观察性研究、临床试验以及通过系统性文献检索获得的其他二次研究:安非他酮和右美沙芬的组合作为一种新的心理健康药物疗法,是对 MDD 治疗方案的一种有趣的补充。这种联合用药可用于多种情况,包括作为一线疗法,在患者使用血清素靶向药物未能达到缓解时作为第二选择,以及用于治疗耐药抑郁症。针对其他适应症(包括成瘾症)的进一步研究可能会带来令人振奋的结果。虽然这是一种新的组合,但临床医生将非常熟悉这两种药物,从而提高其可接受性。这种药物疗法还可能为发现其他可能具有有益协同作用的组合提供更多动力。
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Profiling the combination of bupropion and dextromethorphan as a treatment option for major depressive disorder.

Introduction: Major Depressive Disorder (MDD) is a common mental health disorder marked by sadness, hopelessness, and anhedonia. Various therapies exist, but their effectiveness is limited. Dextromethorphan hydrobromide combined with bupropion hydrochloride (Auvelity®) is a recently approved alternative for treating this condition in adults.

Areas covered: This review summarizes the neurobiology of major depression and delves into the pharmacology, efficacy, safety, and tolerability of dextromethorphan plus bupropion in adult patients. It is based on observational studies, clinical trials, and other secondary studies obtained through systematic literature searches.

Expert opinion: The combination of bupropion and dextromethorphan as a new pharmacotherapy for mental health is an interesting addition to the treatment options that can be used for MDD. The combination can be used in a range of scenarios, including as a first line therapy, as a second option when a patient has failed to achieve remission with a serotonin targeting agent, and for treatment resistant depression. Further research for other indications, including addiction disorders, may provide exciting results. Although a new combination, clinicians will be very familiar with both agents, increasing their acceptability. This pharmacotherapy also may bring increased impetus for discovering other combinations that may have beneficial synergistic effects.

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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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