功能连接与青少年痛经特征的关联:对三重网络模型的研究。

IF 5.9 1区 医学 Q1 ANESTHESIOLOGY PAIN® Pub Date : 2025-02-01 Epub Date: 2024-07-18 DOI:10.1097/j.pain.0000000000003334
Laura A Payne, Laura C Seidman, Vitaly Napadow, Lisa D Nickerson, Poornima Kumar
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引用次数: 0

摘要

摘要:痛经与中枢疼痛处理缺陷有关,但迄今为止的神经影像学研究都局限于对有痛经与无痛经的成年女性进行分组比较。本研究旨在调查大脑网络三重网络模型(TNM)在月经疼痛严重程度不同的少女中的作用。100名参与者(13-19岁)完成了6分钟静息状态功能磁共振成像(fMRI)扫描,并对经痛严重程度、经痛干扰和累积经痛暴露进行了评级。成像分析将年龄和妇科年龄(月经初潮后的年数)作为协变量。经痛严重程度与脑回-小脑突出网络(cSN)、感觉处理区、边缘区和岛叶之间的功能连接呈正相关,与左侧中央执行网络(CEN)和后部区域之间的连接也呈正相关。经痛干扰与 cSN 和广泛脑区之间的连通性呈正相关。此外,经痛干扰与左侧 CEN 内部的连接性呈正相关,而右侧 CEN 内部以及右侧 CEN 与网络外皮层区域(包括岛叶)之间的连接性与经痛干扰呈负相关。累积的经痛暴露与默认模式网络和其他与大规模大脑网络相关的广泛区域之间的连通性呈强烈的负相关。这些研究结果支持TNM脑网络在经痛特征中的关键作用,并表明不同程度经痛的青少年在疼痛处理过程中存在改变。
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Functional connectivity associations with menstrual pain characteristics in adolescents: an investigation of the triple network model.

Abstract: Menstrual pain is associated with deficits in central pain processing, yet neuroimaging studies to date have all been limited by focusing on group comparisons of adult women with vs without menstrual pain. This study aimed to investigate the role of the triple network model (TNM) of brain networks in adolescent girls with varied menstrual pain severity ratings. One hundred participants (ages 13-19 years) completed a 6-min resting state functional magnetic resonance imaging (fMRI) scan and rated menstrual pain severity, menstrual pain interference, and cumulative menstrual pain exposure. Imaging analyses included age and gynecological age (years since menarche) as covariates. Menstrual pain severity was positively associated with functional connectivity between the cingulo-opercular salience network (cSN) and the sensory processing regions, limbic regions, and insula, and was also positively associated with connectivity between the left central executive network (CEN) and posterior regions. Menstrual pain interference was positively associated with connectivity between the cSN and widespread brain areas. In addition, menstrual pain interference was positively associated with connectivity within the left CEN, whereas connectivity both within the right CEN and between the right CEN and cortical areas outside the network (including the insula) were negatively associated with menstrual pain interference. Cumulative menstrual pain exposure shared a strong negative association with connectivity between the default mode network and other widespread regions associated with large-scale brain networks. These findings support a key role for the involvement of TNM brain networks in menstrual pain characteristics and suggest that alterations in pain processing exist in adolescents with varying levels of menstrual pain.

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来源期刊
PAIN®
PAIN® 医学-临床神经学
CiteScore
12.50
自引率
8.10%
发文量
242
审稿时长
9 months
期刊介绍: PAIN® is the official publication of the International Association for the Study of Pain and publishes original research on the nature,mechanisms and treatment of pain.PAIN® provides a forum for the dissemination of research in the basic and clinical sciences of multidisciplinary interest.
期刊最新文献
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