尚未满足的需求:胰腺β细胞替代

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Samj South African Medical Journal Pub Date : 2024-04-24 DOI:10.7196/SAMJ.2024.v114i3b.1249
F Mohamed, C Adams, B Mansfield
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引用次数: 0

摘要

糖尿病(DM)是南非(SA)日益严重的公共卫生问题,也给全球医疗保健带来了巨大的经济负担。自胰岛素被发现以来已经过去了一个世纪,尽管在糖尿病管理方面取得了进展,但外源性胰岛素仍是治疗 1 型糖尿病的主要方法,并带来了高血糖和低血糖的挑战。胰腺移植应被视为胰岛素缺乏性糖尿病的一种治疗方法,它能提供持续的优格血症并预防与该疾病相关的并发症。然而,在全球范围内进行的移植数量却在减少。在南澳大利亚,只有少数人进行了胰腺移植,主要原因是手术风险和需要免疫抑制。胰岛移植是一种替代方法,但由于供体稀缺和免疫抑制的要求而面临局限性。本综述探讨了胰腺和胰岛移植治疗糖尿病的最新进展,旨在为胰岛素缺乏性糖尿病患者提供更多的治疗选择。
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An unmet need: Pancreatic beta cell replacement.

Diabetes mellitus (DM) is a growing public health concern in South Africa (SA) and poses a substantial economic burden on healthcare globally. A century has passed since the discovery of insulin, and despite advances in diabetes management, exogenous insulin remains a primary treatment for type 1 DM, posing challenges of hyperglycaemia and hypoglycaemia. Pancreas transplantation should be considered a treatment for insulin-deficient DM, offering sustained euglycaemia and preventing complications associated with the disease. However, there has been a global decrease in the number of transplants performed. In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. This review explores recent progress in pancreas and islet transplants for DM, with the aim of providing insights into expanding treatment options for people with insulin-deficient DM.

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来源期刊
Samj South African Medical Journal
Samj South African Medical Journal 医学-医学:内科
CiteScore
3.00
自引率
4.50%
发文量
175
审稿时长
4-8 weeks
期刊介绍: The SAMJ is a monthly peer reviewed, internationally indexed, general medical journal. It carries The SAMJ is a monthly, peer-reviewed, internationally indexed, general medical journal publishing leading research impacting clinical care in Africa. The Journal is not limited to articles that have ‘general medical content’, but is intending to capture the spectrum of medical and health sciences, grouped by relevance to the country’s burden of disease. This will include research in the social sciences and economics that is relevant to the medical issues around our burden of disease The journal carries research articles and letters, editorials, clinical practice and other medical articles and personal opinion, South African health-related news, obituaries, general correspondence, and classified advertisements (refer to the section policies for further information).
期刊最新文献
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