药用大麻茶含有不同剂量的大麻素,不含萜烯。

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY Basic & Clinical Pharmacology & Toxicology Pub Date : 2024-07-23 DOI:10.1111/bcpt.14056
Marie Bach Sønderskov, Jørgen Bo Hasselstrøm, Rime Bahij, Charlotte Uggerhøj Andersen
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引用次数: 0

摘要

在丹麦,茶是处方大麻植物产品的一种推荐给药方式。我们的目的是调查不同茶叶中所含的大麻素和萜烯的剂量。我们分析了四氢大麻酚 (THC)、四氢大麻酚酸 (THCA)、大麻二酚 (CBD)、大麻二酸 (CBDA) 和萜烯在每种茶的三种重复制剂中的浓度,以及在植物材料中的浓度。在标准茶叶中,标示总四氢大麻酚(四氢大麻酚 + 四氢大麻酸)含量为 6.3%、14% 和 22% 的产品中,四氢大麻酚的浓度[中位数(最小值-最大值)]分别为 9.5(2.3-15)、19(13-34)和 36(26-57)微克/毫升。标示为总生物多糖含量 8%(生物多糖 + CBDA)的产品茶叶中的生物多糖浓度为 7.5(1.9-10)微克/毫升。据此,0.2 升不同茶叶的推荐起始量将含有 0.46 至 11.3 毫克四氢大麻酚和 0.38 至 2.0 毫克 CBD。在煮沸前添加奶精(而非煮沸后添加)会使四氢大麻酚和大麻二酚的浓度分别增加 2.3-4.4 倍和 2.1 倍。在植物材料中检测到了萜烯,但在茶叶中没有检测到。这项研究阐明了不同茶叶中的四氢大麻酚和大麻二酚剂量,这可能有助于临床医生选择大麻产品。此外,它还强调了谨慎用药的必要性,因为即使使用相同的大麻产品,饮茶也会导致接触到不同的剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Medicinal cannabis tea contains variable doses of cannabinoids and no terpenes

Tea is a recommended way of administration of prescribed cannabis plant products in Denmark. We aimed to investigate the cannabinoid and terpene doses contained in different teas. We analysed tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and terpene concentrations in three repeated preparations of each type of tea, and in plant material.

In standard tea, concentrations of THC were [median (min-max)] 9.5 (2.3–15), 19 (13–34), and 36 (26–57) μg/mL for products with a labelled content of 6.3%, 14%, and 22% total THC (THC + THCA), respectively. The CBD concentration in tea from a product labelled with 8% total CBD (CBD + CBDA) was 7.5 (1.9–10) μg/mL. Based on this, the recommended starting amount of 0.2 L of the different teas would contain between 0.46 and 11.3 mg THC, and 0.38 to 2.0 mg CBD. Adding creamer before, but not after boiling, increased the THC and CBD concentration 2.3–4.4 and 2.1-fold, respectively. Terpenes were detected in plant material, but not in tea.

The study elucidates THC and CBD doses in different teas, which may assist the clinician's choice of cannabis product. Moreover, it underscores the need for caution as administration as tea can result in exposure to different doses, even when the same cannabis product is used.

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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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