炎症变化与高危军人的心理风险和复原力有关吗?

IF 1.4 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Bmj Military Health Pub Date : 2024-09-20 DOI:10.1136/military-2024-002725
Neanne Bennett, E Lawrence-Wood, A McFarlane
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引用次数: 0

摘要

导言:在军人群体中,由于创伤后应激障碍(PTSD)症状可能被低报,而且在识别早期变化方面存在挑战,因此很难检测出新出现的障碍。然而,如果能及早发现创伤后应激障碍症状,就能增加干预的机会,并有可能降低出现慢性心理健康问题的可能性:本研究探讨了用 C 反应蛋白(CRP)和白细胞介素 6(IL-6)测量的炎症水平的变化是否与创伤后应激障碍相关心理症状的出现有关。研究还考察了炎症随时间的变化是否会导致心理风险和复原力,复原力的定义是对部署相关的战斗暴露的心理反应能力。参与者是特种部队人员,他们填写了心理自我报告问卷,并在部署前和部署后测量了 CRP 和 IL-6。研究人员使用回归分析来研究心理症状如何预测炎症的变化,并使用方差分析(ANOVA)来研究已确定的亚组之间的差异:结果:研究结果表明,这些人群暴露于战斗和创伤的程度较高,而心理症状程度较低。结果还发现,随着时间的推移,CRP 有所下降,IL-6 有所上升。不同亚组之间的炎症指标存在明显差异(p 结论:这些初步研究结果表明,炎症指标在不同亚组之间存在明显差异:这些初步研究结果表明,炎症标志物可能有助于识别部署后的适应性反应。此外,炎症标志物的低水平增加可能与阈下创伤后应激障碍症状有关。这些发现为军队和退伍军人群体的预防、早期识别和治疗提供了潜在的启示。
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Is inflammatory change associated with psychological risk and resilience in high-risk military personnel?

Introduction: In military populations, the potential for under-reporting of Post-traumatic Stress Disorder (PTSD) symptoms and challenges in recognising early changes can make it difficult to detect an emerging disorder. However, early identification of PTSD symptoms would improve opportunities for intervention, and potentially reduce the likelihood of chronic mental health problems.

Method: This study explored if changes in levels of inflammation, measured by C reactive protein (CRP) and interleukin 6 (IL-6), were associated with the onset of psychological symptoms associated with PTSD. It also examined if changes in inflammation over time contributed to psychological risk and resilience, which was defined by psychological reactivity to deployment-related combat exposures. Participants were special forces personnel who completed psychological self-report questionnaires and had measures of CRP and IL-6 taken pre and post deployment. Regression analysis was used to examine how psychological symptoms predicted change in inflammation, and Analysis of Variance (ANOVA) were used to examine differences between identified subgroups.

Results: Results identify this population as having high levels of combat and trauma exposures, with low-level psychological symptoms. The results also identified a decrease in CRP and an increase in IL-6 over time. A significant difference in inflammation was identified between subgroups (p<0.05). An association between inflammatory markers and subthreshold symptoms related to anger (p<0.01) and sleep (p<0.05) was also identified.

Conclusion: These preliminary findings suggest inflammatory markers may help to identify adaptive responses post deployment. In addition, low-level increases in inflammatory markers may be associated with subthreshold PTSD symptoms. These findings offer potential insights for prevention, early identification and treatment in military and veteran populations.

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来源期刊
Bmj Military Health
Bmj Military Health MEDICINE, GENERAL & INTERNAL-
CiteScore
3.10
自引率
20.00%
发文量
116
期刊最新文献
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