帕金森病早期患者的深度睡眠、嗅觉丧失和认知能力:试点研究结果

IF 2.1 Q3 GERIATRICS & GERONTOLOGY Gerontology and Geriatric Medicine Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI:10.1177/23337214241262925
Vanessa M Young, Rebecca Bernal, Erin Pollet, Luis Serrano-Rubio, Carlos Gaona, Jayandra Jung Himali, Sudha Seshadri, David Andrés González, Mitzi M Gonzales
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引用次数: 0

摘要

与年龄匹配的对照组相比,帕金森病(PD)患者患痴呆症的风险更高。快速眼动睡眠行为障碍(RBD)和嗅觉减退会影响症状的严重程度。我们报告了多导睡眠图评估的睡眠结构、嗅觉识别和认知之间的关联。20名患有早期帕金森病的成年人(平均年龄69 ± 7.9岁;25%为女性)完成了认知评估、简短嗅觉识别测试(BSIT)和夜间门诊多导睡眠图检查。通过主成分分析得出了总体认知评分。线性回归模型检验了睡眠变量、BSIT 表现和认知能力之间的关联。对患有和未患有 RBD 的参与者的认知能力进行了比较。深度睡眠(β±SE:1.18±0.45,p = .02)和嗅觉识别(0.37±0.12,p = .01)与更好的认知能力相关。浅睡眠、快速动眼期睡眠、唤醒指数和睡眠效率则与之无关(所有 p > .05)。与没有 RBD 的人相比,有 RBD 的人认知能力明显较差(t 检验 = -1.06 ± 0.44,p = .03);没有人进入深度睡眠。深度睡眠与更好的记忆力(1.20 ± 0.41,p = .01)和执行功能(2.94 ± 1.13,p = .02)相关;睡眠效率与执行功能相关(0.05 ± 0.02,p = .02)。这些研究结果表明,缺乏深度睡眠、嗅觉减退和认知能力较差之间存在相互关系,在帕金森病患者中尤其如此。同时评估这些标记物可以提高对高危人群的早期识别能力,并改善干预措施的使用。
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Deep Sleep, Olfactory Loss, and Cognition in Early-stage Parkinson's Disease: Pilot Study Results.

Individuals with Parkinson's disease (PD) have a higher risk of developing dementia compared to age-matched controls. Rapid eye movement sleep behavior disorder (RBD) and hyposmia can influence symptoms severity. We report associations between polysomnography-assessed sleep architecture, olfactory identification, and cognition. Twenty adults with early-stage PD (mean age 69 ± 7.9; 25% female) completed cognitive assessments, the Brief Smell Identification Test (BSIT), and overnight in-clinic polysomnography. A global cognitive score was derived from principal component analysis. Linear regression models examined associations between sleep variables, BSIT performance, and cognition. Cognitive performance was compared between participants with and without RBD. Deep sleep attainment (β ± SE: 1.18 ± 0.45, p = .02) and olfactory identification (0.37 ± 0.12, p = .01) were associated with better cognition. Light sleep, REM sleep, arousal index, and sleep efficiency were not (all p > .05). Participants with RBD had significantly worse cognition (t-test = -1.06 ± 0.44, p = .03) compared to those without RBD; none entered deep sleep. Deep sleep attainment was associated with better memory (1.20 ± 0.41, p = .01) and executive function (2.94 ± 1.13, p = .02); sleep efficiency was associated with executive function (0.05 ± 0.02, p = .02). These findings suggest interrelationships between lack of deep sleep, hyposmia, and poorer cognition in PD, particularly among individuals with RBD. Assessing these markers together may improve early identification of high-risk individuals and access to interventions.

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来源期刊
Gerontology and Geriatric Medicine
Gerontology and Geriatric Medicine Medicine-Geriatrics and Gerontology
CiteScore
2.90
自引率
3.70%
发文量
119
审稿时长
12 weeks
期刊介绍: Gerontology and Geriatric Medicine (GGM) is an interdisciplinary, peer-reviewed open access journal where scholars from a variety of disciplines present their work focusing on the psychological, behavioral, social, and biological aspects of aging, and public health services and research related to aging. The journal addresses a wide variety of topics related to health services research in gerontology and geriatrics. GGM seeks to be one of the world’s premier Open Access outlets for gerontological academic research. As such, GGM does not limit content due to page budgets or thematic significance. Papers will be subjected to rigorous peer review but will be selected solely on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, GGM facilitates the discovery of the connections between papers.
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