Fırat Tevetoğlu, Nil Çomunoğlu, Haydar Murat Yener
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Pathology specimens were evaluated using immunohistochemistry to assess the expressions of the CD3, CD20, CD8, CD4, CD25, and FoxP3 markers, identifying subgroups of TILs. The investigation aimed to uncover how these subgroups influence tumor histopathological features and survival outcomes. The high infiltration of CD3, CD20, and CD4 had a positive impact on disease-specific survival, disease-free survival, and recurrence-free survival. In addition, overall survival was positively affected by high CD3 and CD4 infiltrations. However, no significant relationship was observed between the expressions of CD8, FoxP3, and CD25 and any of the survival parameters. The infiltration of CD3, CD20, and CD4 positive cells indicative of a robust antitumoral immune response-emerged as favorable prognostic factors in laryngeal cancer. 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引用次数: 0
摘要
由于包括喉癌在内的各种癌症的生存率都没有提高,人们对了解癌症的免疫反应越来越感兴趣。在头颈部癌症中,免疫微环境和免疫浸润等免疫调节机制在癌症发病机制中起着重要作用。本研究旨在探索肿瘤浸润淋巴细胞(TIL)亚群在免疫微环境中的分布,并评估其对肿瘤组织病理学特征和预后的影响。研究纳入了2016年1月至2018年1月期间在伊斯坦布尔大学(Istanbul University - Cerrahpaşa, Faculty of Medicine)耳鼻喉科接受喉鳞癌切除术的50名患者。病理标本采用免疫组化方法进行评估,以评估 CD3、CD20、CD8、CD4、CD25 和 FoxP3 标记的表达,从而确定 TILs 亚群。调查旨在揭示这些亚群如何影响肿瘤组织病理学特征和生存结果。CD3、CD20和CD4的高浸润率对疾病特异性生存率、无病生存率和无复发生存率有积极影响。此外,CD3和CD4高浸润对总生存率也有积极影响。然而,CD8、FoxP3 和 CD25 的表达与任何生存参数之间都没有明显的关系。CD3、CD20和CD4阳性细胞的浸润表明了强大的抗肿瘤免疫反应,成为喉癌的有利预后因素。这些发现表明,增强 CD3、CD20 和 CD4 淋巴细胞的浸润可能是一种值得在临床试验中探索的治疗策略。
The impact of the tumor immune microenvironment and tumor-infiltrating lymphocyte subgroups on laryngeal cancer prognosis.
The absence of improvement in survival rates across various cancers, including laryngeal cancer, has led to an increasing interest in understanding the immune response to cancer. In head and neck cancers, immune modulatory mechanisms such as immune microenvironment and immune infiltration are important in cancer pathogenesis. This study aims to explore the distribution of tumor-infiltrating lymphocyte (TIL) subgroups in the immune microenvironment and evaluate their impact on tumor histopathological characteristics and prognosis. The study included 50 patients who underwent laryngectomy for laryngeal squamous cell carcinoma, in Istanbul University - Cerrahpaşa, Faculty of Medicine Department of Otorhinolaryngology, between January 2016 and January 2018. Pathology specimens were evaluated using immunohistochemistry to assess the expressions of the CD3, CD20, CD8, CD4, CD25, and FoxP3 markers, identifying subgroups of TILs. The investigation aimed to uncover how these subgroups influence tumor histopathological features and survival outcomes. The high infiltration of CD3, CD20, and CD4 had a positive impact on disease-specific survival, disease-free survival, and recurrence-free survival. In addition, overall survival was positively affected by high CD3 and CD4 infiltrations. However, no significant relationship was observed between the expressions of CD8, FoxP3, and CD25 and any of the survival parameters. The infiltration of CD3, CD20, and CD4 positive cells indicative of a robust antitumoral immune response-emerged as favorable prognostic factors in laryngeal cancer. These findings suggest that enhancing the infiltration of CD3, CD20, and CD4 lymphocytes could be a therapeutic strategy worth exploring in clinical trials.
期刊介绍:
Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.