Undobolins A-L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL Journal of Natural Products Pub Date : 2024-08-23 Epub Date: 2024-07-25 DOI:10.1021/acs.jnatprod.4c00385

Yuyi Zheng, Qin Li, Minglang Gu, Hong Liao, Yu Liang, Fei Liu, Xiao-Nian Li, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu

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引用次数: 0

摘要

通过光谱分析、ECD 计算和单晶 X 射线衍射实验阐明了它们的结构。化合物 1 是第二个被报道的 20-去甲硫代异丁烯的例子，而化合物 2-6 的显著特点是 C-2 的含氧，化合物 6 对 ConA 诱导的 T 淋巴细胞增殖具有显著的抑制活性，IC50 值为 2.3 μM，这为寻找免疫抑制剂提供了新的方向。

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Undobolins A-L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus.

Twelve previously undescribed ophiobolin-type sesterterpenoids, undobolins A-L (1-12), were isolated from Aspergillus undulatus, and their structures were elucidated by spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction experiments. Compound 1 was the second example of 20-nor-ophiobolin reported, while compounds 2-6 were notable for oxygenation of C-2, and compound 6 showed significant inhibitory activity against ConA-induced T lymphocyte proliferation with an IC₅₀ value of 2.3 μM, which suggests a promising new direction in the quest for immunosuppressive agents.

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.