镉的心脏毒性及其对雏鸡早期和晚期胚胎发育过程中心脏效率的影响

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI:10.1007/s12012-024-09894-x
Reda A Ali, Eatemad A Awadalla, Amal S Hamed, Dalia Elzahraa F Mostafa
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引用次数: 0

摘要

镉(Cd)是一种危险的重金属,在环境中不可降解。许多器官都会积聚镉,对器官功能和健康产生不利影响。镉被认为具有致畸和胚胎毒性。本研究旨在评估镉在低于允许浓度时的致畸性及其对小鸡胚胎发育过程中心脏的影响。受精卵分为对照组、注射生理盐水组和注射单剂量 5、25、50 或 75 µM 氯化镉的四个实验组。对孵化前的心脏和孵化后的心肌细胞进行组织学观察。在孵化 3、4 和 6 天时对心腔进行形态测量。第十天记录心电图和呼吸频率。镉引起了不同的心脏问题。与对照组相比,小鼠的心脏看起来要大得多,在某些情况下还会出现生长迟缓。还发现心壁退化和背主动脉畸形。从形态学角度看,心室的宽度和壁厚发生了显著变化。与对照组相比,心跳和呼吸频率明显下降。镉对心脏结构和功能的毒性作用与剂量有关。镉的毒性之一是其诱导细胞氧化应激的能力。心脏对氧化应激尤其敏感。心脏氧化应激可能会加剧心力衰竭并促进疾病进展。钙是心脏正常工作所需的成分之一。镉可能会将钙排出体外,从而干扰钙的代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis.

Cadmium (Cd) is a dangerous heavy metal that is non-degradable in the environment. Many organs can accumulate Cd and adversely affect organ function and health. Cd is considered as a teratogenic and embryotoxic agent. This study aims to evaluate the teratogenicity of Cd at concentrations lesser than the permissible and its effects on the heart during chick embryogenesis. Fertilized eggs of the chick Gallus domesticus were divided into; control, saline injected and four experimental groups injected with single doses of 5, 25, 50 or 75 µM of CdCl2. Histological observations of the heart before hatching and the cardiomyocytes after hatching were recorded. Morphometric measurements of heart chambers were achieved at 3, 4 and 6 days of incubation. Electrocardiograph and respiratory rate were recorded at tenth day. Different cardiac problems had been brought on by Cd. In comparison to controls, the heart looked much larger, and in certain cases, growth retardation was seen. Degeneration in heart walls and malformations of dorsal aorta were noticed. Morphometrically, the width and wall thickness of heart chambers showed significant changes. Heart beats and respiratory rate significantly decreased compared to control. The cardiotoxic effect of Cd on heart compartments structure and function was dose dependent. One of Cd toxicity is its ability to induce cellular oxidative stress. The heart in particular is sensitive to oxidative stress. Cardiac oxidative stress might intensify heart failure and promote disease progression. Calcium is one of the components that is needed for normal heart work. Cd might interfere with calcium metabolism by removing it from the body.

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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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