局部晚期胰腺癌的立体定向体放射治疗

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Experimental Gastroenterology Pub Date : 2024-07-16 eCollection Date: 2024-01-01 DOI:10.2147/CEG.S341189
Shane S Neibart, Shalini Moningi, Krishan R Jethwa
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引用次数: 0

摘要

简介:对于适合接受放射治疗的局部晚期胰腺癌(LAPC)患者,剂量递增放射治疗(RT)与传统放射技术相比具有独特的优势。在本综述中,我们将从历史角度介绍剂量递增 RT 治疗局部晚期胰腺癌的情况。我们还概述了 SBRT 放射治疗的进展、剂量升级的一种形式以及选择患者接受 SBRT 治疗的框架:结果:为LAPC患者提供SBRT的技术已经有了很大的发展,现在可以实现剂量升级和出色的呼吸运动管理。与此同时,全身治疗的进步,尤其是诱导多试剂化疗的使用,使人们对哪些患者能从放疗中获益最大产生了疑问。对 LAPC 患者进行多学科评估对于指导治疗和选择接受局部治疗的患者至关重要。正在进行的试验结果将确定,在诱导化疗后,经过仔细筛选的患者是否可以接受剂量递增的SBRT治疗:结论:LAPC 患者拥有比以往更多的治疗选择。结论:LAPC 患者拥有比以往更多的治疗选择,在关键性临床试验成熟之前,谨慎选择 SBRT 可提高患者的治疗效果。
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Stereotactic Body Radiation Therapy for Locally Advanced Pancreatic Cancer.

Introduction: For patients with locally advanced pancreatic cancer (LAPC), who are candidates for radiation therapy, dose-escalated radiation therapy (RT) offers unique benefits over traditional radiation techniques. In this review, we present a historical perspective of dose-escalated RT for LAPC. We also outline advances in SBRT delivery, one form of dose escalation and a framework for selecting patients for treatment with SBRT.

Results: Techniques for delivering SBRT to patients with LAPC have evolved considerably, now allowing for dose-escalation and superior respiratory motion management. At the same time, advancements in systemic therapy, particularly the use of induction multiagent chemotherapy, have called into question which patients would benefit most from radiation therapy. Multidisciplinary assessment of patients with LAPC is critical to guide management and select patients for local therapy. Results from ongoing trials will establish if there is a role of dose-escalated SBRT after induction chemotherapy for carefully selected patients.

Conclusion: Patients with LAPC have more therapeutic options than ever before. Careful selection for SBRT may enhance patient outcomes, pending the maturation of pivotal clinical trials.

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来源期刊
Clinical and Experimental Gastroenterology
Clinical and Experimental Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.10
自引率
0.00%
发文量
26
审稿时长
16 weeks
期刊最新文献
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