小球藻细胞和孢子 SF174 对果糖引起的小肠和大肠肠道功能紊乱的保护作用。

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Nutritional Biochemistry Pub Date : 2024-07-23 DOI:10.1016/j.jnutbio.2024.109706
Anella Saggese , Valentina Barrella , Angela Di Porzio , Antonio Dario Troise , Andrea Scaloni , Luisa Cigliano , Giovanni Scala , Loredana Baccigalupi , Susanna Iossa , Ezio Ricca , Arianna Mazzoli
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引用次数: 0

摘要

如今,口服益生菌已被认为是治疗或预防不健康饮食习惯后果的一种策略。在这里,我们分析并比较了在大鼠模型中口服克劳氏寿昌菌(Shouchella clausii)SF174 的无性细胞或孢子对抵消高果糖摄入 6 周引起的肠道功能障碍的影响。我们在大鼠回肠和结肠中评估了肠道微生物群组成、紧密连接蛋白、炎症标志物和氧化还原平衡。结果表明,SF174 的孢子和细胞都能有效防止果糖引起的肠道代谢损伤,即建立 "漏损肠道"、炎症和氧化损伤,从而保护肠道功能。我们的研究结果还表明,无性细胞和发芽衍生细胞可在回肠水平代谢摄入的部分果糖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Protective role of cells and spores of Shouchella clausii SF174 against fructose-induced gut dysfunctions in small and large intestine

The oral administration of probiotics is nowadays recognized as a strategy to treat or prevent the consequences of unhealthy dietary habits. Here we analyze and compare the effects of the oral administration of vegetative cells or spores of Shouchella clausii SF174 in counteracting gut dysfunctions induced by 6 weeks of high fructose intake in a rat model. Gut microbiota composition, tight junction proteins, markers of inflammation and redox homeostasis were evaluated in ileum and colon in rats fed fructose rich diet and supplemented with cells or spores of Shouchella clausii SF174. Our results show that both spores and cells of SF174 were effective in preventing the fructose-induced metabolic damage to the gut, namely establishment of “leaky gut”, inflammation and oxidative damage, thus preserving gut function. Our results also suggest that vegetative cells and germination-derived cells metabolize part of the ingested fructose at the ileum level.

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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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