鼓室内利多卡因是治疗突发性感音神经性耳聋耳鸣的有效药物：一项双盲随机临床试验。

IF 2 3区医学 Q3 CLINICAL NEUROLOGY Otology & Neurotology Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI:10.1097/MAO.0000000000004283

Di Zhang, Daibo Li, Ting Chen, Xuefei Feng, Juan Zhang

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引用次数: 0

摘要

目的：本研究评估了鼓室内注射利多卡因缓解突发性感音神经性听力损失（SSNHL）患者耳鸣的有效性和安全性：本研究评估了鼓室内利多卡因对缓解突发性感音神经性听力损失（SSNHL）患者耳鸣的有效性和安全性：在一项双盲随机对照试验中，100 名单侧耳鸣的突发性感音神经性听力损失（SSNHL）患者接受了鼓室内利多卡因或生理盐水加常规治疗。在1个月和3个月时使用耳鸣障碍量表、主观视觉模拟量表和纯音测听法评估治疗效果：结果：根据耳鸣障碍量表和视觉模拟量表，利多卡因组的耳鸣症状明显缓解，但在整个研究期间没有出现纯音听力改善或严重不良反应：结论：鼓室内利多卡因为SSNHL耳鸣提供了一种安全、有效的治疗方案。由于 SSNHL 的异质性，进一步的研究应完善剂量和给药参数。

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Intratympanic Lidocaine as a Potent Remedy for Tinnitus in Sudden Sensorineural Hearing Loss: A Double-Blind, Randomized Clinical Trial.

Objective: This study evaluates intratympanic lidocaine's efficacy and safety for tinnitus relief in sudden sensorineural hearing loss (SSNHL) patients.

Methods: In a double-blind randomized controlled trial, 100 SSNHL patients with unilateral tinnitus received either intratympanic lidocaine or saline plus usual care. Treatment impact was assessed at 1 and 3 months using the Tinnitus Handicap Inventory, subjective visual analog scale, pure-tone audiometry.

Results: The lidocaine group demonstrated significant tinnitus relief according to the Tinnitus Handicap Inventory and visual analog scale, without pure-tone audiometry improvement or serious adverse events throughout the study period.

Conclusion: Intratympanic lidocaine provides a safe, efficacious treatment option for SSNHL tinnitus. Further studies should refine the dosage and delivery parameters because of SSNHL's heterogenous nature.

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来源期刊

Otology & Neurotology 医学-耳鼻喉科学

CiteScore

3.80

自引率

14.30%

发文量

509

审稿时长

3-6 weeks

期刊介绍： Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.