原发性免疫性血小板减少症患儿的白细胞介素(IL)-1B 和 IL-1 受体拮抗剂基因多态性。

IF 3.2 Q1 PEDIATRICS Clinical and Experimental Pediatrics Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI:10.3345/cep.2024.00577
Seham Mohamed Ragab, Wafaa Moustafa Abo ElFotoh, Mahmoud Ahmed El-Hawy, Eman Abdelfatah Badr, Saara Khairat Ali Mostafa, Mai El-Sayad Abd El-Hamid
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引用次数: 0

摘要

背景:目的:研究儿童原发性ITP的易感性和严重程度与IL-1B和IL-1R拮抗剂基因多态性之间的关系:这项病例对照比较研究于 2022 年 8 月至 2023 年 9 月在梅努菲亚大学医院儿科血液学和肿瘤学组进行。患儿分为接受住院和门诊治疗的患者(28 名男孩,22 名女孩)和对照组(50 名年龄和性别匹配的健康儿童):结果:IL1B 基因 rs16944 的突变同源 GG 基因型和突变 G 等位基因在患者中的比例明显高于对照组(PConclusion:IL-1B 和 IL-1R 拮抗剂可能对免疫性血栓性全血细胞减少症的发病有重大影响。此外,我们还发现了 IL-1B 和 IL-1R 拮抗剂基因多态性与儿童血栓性白血病病因之间的关系。
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Interleukin (IL)-1B and IL-1 receptor antagonist gene polymorphisms in children with primary immune thrombocytopenia.

Background: The pathophysiology and susceptibility of children to primary immune thrombocytopenia (ITP) are linked to polymorphisms of the interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonist genes.

Purpose: To investigate the association between the susceptibility and severity of primary ITP in children and the IL-1B and IL-1R antagonist gene polymorphisms.

Methods: This comparative case-control study was conducted at the Menoufia University Hospital Hematology and Oncology Unit, Pediatric Department, between August 2022 and September 2023. The children were divided into patients (28 boys, 22 girls) who received hospital and outpatient clinic care and controls (50 healthy age- and sex-matched children).

Results: The mutant homozygous GG genotype and mutant G allele of rs16944 of the IL1B gene were considerably greater in patients than in controls (P<0.001). Furthermore, the mutant homozygous II/II genotype and heterozygous I/II genotype of the IL-1R antagonist gene were considerably greater in the case versus control group. The mutant II allele was significantly more prevalent in patients versus controls (P<0.001).

Conclusion: IL-1B and IL-1R antagonists may have a major impact on the development of immune thrombocytopenia. Furthermore, we found a relationship between IL-1B and IL-1R antagonist gene polymorphisms and the etiology of and children's susceptibility to primary immune thrombocytopenia.

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来源期刊
CiteScore
8.00
自引率
2.40%
发文量
88
审稿时长
60 weeks
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