阴道微生态失调对中国人类免疫缺陷病毒感染妇女宫颈细胞学异常风险增加的影响。

IF 5 2区医学 Q2 IMMUNOLOGY Journal of Infectious Diseases Pub Date : 2024-07-25 DOI:10.1093/infdis/jiae058

Xiaolei Wang, Yuanyuan Zhang, Jiang Xiao, Chuan Song, Tingting Liu, Jun Liu, Hongxin Zhao

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引用次数: 0

摘要

背景：感染人类免疫缺陷病毒（WWH）的妇女通常会出现宫颈细胞学异常：人类免疫缺陷病毒感染妇女（WWH）通常会出现宫颈细胞学异常：方法：对在北京地坛医院接受妇科检查的 130 名 WWH 和 147 名年龄匹配的健康对照者进行了横断面研究。结果：多变量 logistic 回归分析预测了 WWH 宫颈细胞学异常的发生率：结果：多变量逻辑回归发现了3个独立因素，其中CD4细胞计数≥350 cells/μL是保护因素，而人乳头瘤病毒感染和阴道pH值异常是危险因素：阴道微生态失调会增加WWH宫颈细胞学异常的风险。

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Effect of Vaginal Microecological Disorders on the Increased Risk of Abnormal Cervical Cytology Among Women With Human Immunodeficiency Virus in China.

Background: Abnormal cervical cytology is commonly observed in women with human immunodeficiency virus (WWH).

Methods: A cross-sectional study was conducted with 130 WWH and 147 age-matched healthy controls, who underwent gynecological examinations at Beijing Ditan Hospital. The presence of abnormal cervical cytology in WWH was predicted after performing a logistic regression analysis.

Results: Multivariate logistic regression revealed 3 independent factors, among which CD4 cell count ≥350 cells/μL was the protective factor, while human papillomavirus infection and abnormal vaginal pH were the risk factors.

Conclusions: Vaginal microecological disorders can increase the risk of abnormal cervical cytology in WWH.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.