血管生成素 2 的水平可预测黄热病病毒感染者的死亡率

IF 5 2区医学 Q2 IMMUNOLOGY Journal of Infectious Diseases Pub Date : 2024-07-25 DOI:10.1093/infdis/jiad389

Cornelia A M van de Weg, Mateus V Thomazella, Mariana P Marmorato, Carolina A Correia, Juliana Z C Dias, Alvino Maestri, Luiz G F A B E Zanella, Natalia B Cerqueira, Alvina C Félix, Carlos H V Moreira, Renata Buccheri, Priscilla R Costa, Esper G Kallás

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引用次数: 0

摘要

2018 年，巴西圣保罗爆发了大规模黄热病疫情，死亡率很高。黄热病病毒可引起出血和弥散性血管内凝血等症状，表明内皮细胞在疾病发病机制中发挥作用。在此，我们进行了一项病例对照研究，测量了血浆中与内皮损伤有关的标记物及其与死亡率的关系。我们发现血管生成素 2 与死亡结果密切相关，可作为预测死亡率的标志物。这可用于监测严重病例，并提供护理以改善疾病预后。

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Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.

In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.