RNA 修饰在癌症转移中的作用

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI:10.1016/j.gde.2024.102232
Nofar Malka-Tunitsky , Aldema Sas-Chen
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引用次数: 0

摘要

表转录组包括在各种 RNA 中发现的 170 多种转录后修饰。RNA 修饰通过塑造 RNA 的结构和功能,在调节基因表达方面发挥着关键作用,从而使表转录组与包括病理进展在内的各种生物过程产生联系。本综述将重点阐述表转录组在癌症转移中的作用。转移是实体瘤患者死亡的主要原因,涉及肿瘤细胞从原发肿瘤向远处继发器官迁移的多步骤过程。我们讨论了在 rRNA、tRNA 和 mRNA 上发现的 RNA 修饰,强调了它们在转移不同阶段的作用。了解转移过程中修饰对分子和细胞过程的调控机制对于利用表转录组特征进行癌症诊断和治疗至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Role of RNA modifications in cancer metastasis

The epitranscriptome encompasses over 170 post-transcriptional modifications found in various RNA species. RNA modifications play pivotal roles in regulating gene expression by shaping RNA structure and function, implicating the epitranscriptome in diverse biological processes, including pathology progression. This review focuses on research elucidating the roles of the epitranscriptome in cancer metastasis. Metastasis, a primary cause of solid tumor patient mortality, involves a multistep process whereby tumor cells migrate from a primary tumor to distant secondary organs. We discuss RNA modifications found on rRNA, tRNA, and mRNA, highlighting their roles in different stages of metastasis. Understanding mechanisms by which modifications regulate molecular and cellular processes during metastasis is crucial for leveraging epitranscriptomic signatures in cancer diagnosis and treatment.

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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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