Yan Gan , Junjie Ying , Xia Qiu , Siyi You , Ting Zhang , Tiechao Ruan , Ruixi Zhou , Yanxiu Ye , Yan Yue , Li Zhang , Dezhi Mu
{"title":"近红外光谱在评估新生儿坏死性小肠结肠炎风险方面的价值：系统回顾和荟萃分析。","authors":"Yan Gan , Junjie Ying , Xia Qiu , Siyi You , Ting Zhang , Tiechao Ruan , Ruixi Zhou , Yanxiu Ye , Yan Yue , Li Zhang , Dezhi Mu","doi":"10.1016/j.earlhumdev.2024.106083","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Recently, near-infrared spectroscopy (NIRS) has been proposed for diagnosing patients with neonatal necrotizing enterocolitis (NEC). However, a consensus on the credibility of NIRS in evaluating NEC risk has not been reached. This meta-analysis aimed to evaluate the relationship between NEC and splanchnic regional tissue oxygen saturation (SrSO<sub>2</sub>) and cerebral regional tissue oxygen saturation (CrSO<sub>2</sub>) detected by NIRS to clarify the clinical value of NIRS in evaluating the risk of NEC.</p></div><div><h3>Methods</h3><p>Studies using NIRS to monitor regional tissue oxygen saturation (rSO<sub>2</sub>) in neonates with NEC published in PubMed, Web of Science, Embase, and the Cochrane Library were searched from their inception to 30 July 2023. Mean difference (MD), pooled sensitivity, and pooled specificity, along with their 95 % confidence intervals (CI), were calculated, and the random-effects model was used for analysis. This study was registered with PROSPERO (no. CRD42022326783).</p></div><div><h3>Results</h3><p>Fourteen studies including 938 neonates (172 NEC, 766 controls) were identified. SrSO<sub>2</sub> was significantly decreased in patients with NEC (MD: -12.52, 95 % CI: −15.95, −9.08; <em>P</em> < 0.00001), and this decrease was observed even before the diagnosis of NEC (MD: -13.79, 95 % CI: −17.97, −9.62; <em>P</em> < 0.00001). The pooled sensitivity and specificity of SrSO<sub>2</sub> were 0.80 (95 % CI: 0.69, 0.88) and 0.90 (95 % CI: 0.61, 0.98), respectively. However, no significant difference in CrSO<sub>2</sub> was found (MD: -4.37, 95 % CI: −10.62, 1.88; <em>P</em> = 0.17).</p></div><div><h3>Conclusions</h3><p>SrSO<sub>2</sub>, detected by NIRS, could be a valuable non-invasive method for differentiating NEC from non-NEC neonates. It could differentiate prior to NEC diagnosis.</p></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"195 ","pages":"Article 106083"},"PeriodicalIF":2.2000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S037837822400152X/pdfft?md5=8690a1794bbe60069ddf0de2ea343c8e&pid=1-s2.0-S037837822400152X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Value of near-infrared spectroscopy in evaluating the risk of neonatal necrotizing enterocolitis: A systematic review and meta-analysis\",\"authors\":\"Yan Gan , Junjie Ying , Xia Qiu , Siyi You , Ting Zhang , Tiechao Ruan , Ruixi Zhou , Yanxiu Ye , Yan Yue , Li Zhang , Dezhi Mu\",\"doi\":\"10.1016/j.earlhumdev.2024.106083\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Recently, near-infrared spectroscopy (NIRS) has been proposed for diagnosing patients with neonatal necrotizing enterocolitis (NEC). However, a consensus on the credibility of NIRS in evaluating NEC risk has not been reached. This meta-analysis aimed to evaluate the relationship between NEC and splanchnic regional tissue oxygen saturation (SrSO<sub>2</sub>) and cerebral regional tissue oxygen saturation (CrSO<sub>2</sub>) detected by NIRS to clarify the clinical value of NIRS in evaluating the risk of NEC.</p></div><div><h3>Methods</h3><p>Studies using NIRS to monitor regional tissue oxygen saturation (rSO<sub>2</sub>) in neonates with NEC published in PubMed, Web of Science, Embase, and the Cochrane Library were searched from their inception to 30 July 2023. Mean difference (MD), pooled sensitivity, and pooled specificity, along with their 95 % confidence intervals (CI), were calculated, and the random-effects model was used for analysis. This study was registered with PROSPERO (no. CRD42022326783).</p></div><div><h3>Results</h3><p>Fourteen studies including 938 neonates (172 NEC, 766 controls) were identified. SrSO<sub>2</sub> was significantly decreased in patients with NEC (MD: -12.52, 95 % CI: −15.95, −9.08; <em>P</em> < 0.00001), and this decrease was observed even before the diagnosis of NEC (MD: -13.79, 95 % CI: −17.97, −9.62; <em>P</em> < 0.00001). The pooled sensitivity and specificity of SrSO<sub>2</sub> were 0.80 (95 % CI: 0.69, 0.88) and 0.90 (95 % CI: 0.61, 0.98), respectively. However, no significant difference in CrSO<sub>2</sub> was found (MD: -4.37, 95 % CI: −10.62, 1.88; <em>P</em> = 0.17).</p></div><div><h3>Conclusions</h3><p>SrSO<sub>2</sub>, detected by NIRS, could be a valuable non-invasive method for differentiating NEC from non-NEC neonates. It could differentiate prior to NEC diagnosis.</p></div>\",\"PeriodicalId\":11435,\"journal\":{\"name\":\"Early human development\",\"volume\":\"195 \",\"pages\":\"Article 106083\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S037837822400152X/pdfft?md5=8690a1794bbe60069ddf0de2ea343c8e&pid=1-s2.0-S037837822400152X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Early human development\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S037837822400152X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early human development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S037837822400152X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：最近，有人提出用近红外光谱（NIRS）诊断新生儿坏死性小肠结肠炎（NEC）患者。然而，关于近红外光谱在评估 NEC 风险方面的可信度尚未达成共识。本荟萃分析旨在评估NEC与近红外光谱检测到的脾脏区域组织氧饱和度（SrSO2）和大脑区域组织氧饱和度（CrSO2）之间的关系，以明确近红外光谱在评估NEC风险方面的临床价值：方法：检索了 PubMed、Web of Science、Embase 和 Cochrane 图书馆中发表的从开始到 2023 年 7 月 30 日使用近红外光谱监测 NEC 新生儿区域组织氧饱和度 (rSO2) 的研究。计算了平均差（MD）、汇总灵敏度、汇总特异性及其 95 % 置信区间（CI），并采用随机效应模型进行分析。本研究已在 PROSPERO 注册（编号：CRD42022326783）：结果：共确定了 14 项研究，包括 938 名新生儿（172 名 NEC，766 名对照组）。NEC 患者的 SrSO2 明显降低（MD：-12.52，95 % CI：-15.95，-9.08；P 2 分别为 0.80（95 % CI：0.69，0.88）和 0.90（95 % CI：0.61，0.98））。然而，CrSO2 没有发现明显差异（MD：-4.37，95 % CI：-10.62，1.88；P = 0.17）：结论：通过近红外光谱检测 SrSO2 是区分 NEC 和非 NEC 新生儿的一种有价值的无创方法。结论：通过近红外光谱检测 SrSO2 是区分 NEC 和非 NEC 新生儿的重要无创方法，可在 NEC 诊断前进行区分。
Value of near-infrared spectroscopy in evaluating the risk of neonatal necrotizing enterocolitis: A systematic review and meta-analysis
Purpose
Recently, near-infrared spectroscopy (NIRS) has been proposed for diagnosing patients with neonatal necrotizing enterocolitis (NEC). However, a consensus on the credibility of NIRS in evaluating NEC risk has not been reached. This meta-analysis aimed to evaluate the relationship between NEC and splanchnic regional tissue oxygen saturation (SrSO2) and cerebral regional tissue oxygen saturation (CrSO2) detected by NIRS to clarify the clinical value of NIRS in evaluating the risk of NEC.
Methods
Studies using NIRS to monitor regional tissue oxygen saturation (rSO2) in neonates with NEC published in PubMed, Web of Science, Embase, and the Cochrane Library were searched from their inception to 30 July 2023. Mean difference (MD), pooled sensitivity, and pooled specificity, along with their 95 % confidence intervals (CI), were calculated, and the random-effects model was used for analysis. This study was registered with PROSPERO (no. CRD42022326783).
Results
Fourteen studies including 938 neonates (172 NEC, 766 controls) were identified. SrSO2 was significantly decreased in patients with NEC (MD: -12.52, 95 % CI: −15.95, −9.08; P < 0.00001), and this decrease was observed even before the diagnosis of NEC (MD: -13.79, 95 % CI: −17.97, −9.62; P < 0.00001). The pooled sensitivity and specificity of SrSO2 were 0.80 (95 % CI: 0.69, 0.88) and 0.90 (95 % CI: 0.61, 0.98), respectively. However, no significant difference in CrSO2 was found (MD: -4.37, 95 % CI: −10.62, 1.88; P = 0.17).
Conclusions
SrSO2, detected by NIRS, could be a valuable non-invasive method for differentiating NEC from non-NEC neonates. It could differentiate prior to NEC diagnosis.
期刊介绍：
Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival.
The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas:
Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
