Maria Laura Sosa Ponce, Jennifer A Cobb, Vanina Zaremberg
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引用次数: 0
摘要
最近的酵母研究揭示了核包膜（NE）结构与脂质代谢之间以及脂质信号转导与表观基因组和基因组完整性之间错综复杂的相互作用。在这篇综述中，我们将重点介绍脂质与组蛋白修饰之间的相互联系，这种联系能使代谢重编程对营养物质做出响应。内质网（ER）-NE 调节着表观遗传代谢产物的分区和时间可用性，其脂质组成也影响着转录沉默和 DNA 损伤应答（DDR）等核过程。我们还讨论了最近的工作，这些工作提供了对细胞核中脂滴（LD）形成和固醇的机理认识，以及显示 Opi1 是膜感应和转录调控脂质-染色质相互关联过程的核心因子的集体数据。
Lipids and chromatin: a tale of intriguing connections shaping genomic landscapes.
Recent studies in yeast reveal an intricate interplay between nuclear envelope (NE) architecture and lipid metabolism, and between lipid signaling and both epigenome and genome integrity. In this review, we highlight the reciprocal connection between lipids and histone modifications, which enable metabolic reprogramming in response to nutrients. The endoplasmic reticulum (ER)-NE regulates the compartmentalization and temporal availability of epigenetic metabolites and its lipid composition also impacts nuclear processes, such as transcriptional silencing and the DNA damage response (DDR). We also discuss recent work providing mechanistic insight into lipid droplet (LD) formation and sterols in the nucleus, and the collective data showing Opi1 as a central factor in both membrane sensing and transcriptional regulation of lipid-chromatin interrelated processes.
期刊介绍：
Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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