对在科希策感染学和旅行医学诊所接受治疗的急性戊型肝炎患者进行分析。

IF 0.5 4区 医学 Q4 MICROBIOLOGY Epidemiologie Mikrobiologie Imunologie Pub Date : 2024-01-01 DOI:10.61568/emi/11-6306/20240424/137083
J Sekula, Z Paraličová
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引用次数: 0

摘要

目的:分析在科希策感染学和旅行医学诊所(CITM)接受治疗的急性戊型肝炎患者的临床、实验室和流行病学数据:对2015-2023年在CITM接受检查或住院治疗的急性戊型肝炎患者的医院信息系统数据进行回顾性分析。对现有数据进行统计评估,重点关注流行病学、病程和并发症:该队列由 62 名患者组成。58%为男性。平均年龄为 56 岁。74%的患者住院治疗,平均住院时间为 10 天。最常见的临床表现是黄疸(40% 的患者)。六名患者进行了粪便 HEV RNA 检测,所有患者均被确诊为基因型 3。5%的患者被归类为输入性感染(他们没有进行HEV RNA检测),95%的病例为自体感染。26%的患者有与 HEV 感染者接触史。13%的患者有肝病史,这些患者的胆红素、GMT和氨水平较高。有免疫缺陷病史的患者在统计学上没有明显差异。一名原有肝病的患者出现了暴发性感染,导致死亡。四名有神经系统症状的戊型肝炎患者胆红素水平较低:研究队列主要包括老年男性。所有接受 HEV RNA 检测的患者均确诊为基因型 3。已患肝病的患者胆红素、氨和 GMT 水平较高。有神经系统并发症的患者胆红素水平较低。一名原有肝病患者死亡。
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Analysis of patients with acute hepatitis E treated at the Clinic of Infectology and Travel Medicine in Košice.

Aim: To analyse clinical, laboratory, and epidemiological data of a cohort of patients with acute hepatitis E treated at the Clinic of Infectology and Travel Medicine (CITM) in Košice.

Material and methods: Retrospective analysis of hospital information system data on patients diagnosed with acute hepatitis E who were examined or hospitalized at CITM in 2015-2023. Statistical evaluation of the available data with a focus on epidemiology, course, and complications.

Results: The cohort consisted of 62 patients. Fifty-eight percent were male. The mean age was 56 years. Seventy-four percent of patients were hospitalized, with a mean length of hospital stay of 10 days. The most common clinical manifestation was jaundice (in 40% of patients). Six patients had stool HEV RNA testing and all were confirmed to have genotype 3. In 5% of patients, the infection was classified as imported (they did not have HEV RNA tested), and 95% of cases were autochthonous. A history of contact with an HEV infected person was reported by 26% of patients. A history of preexisting liver disease was noted in 13% of patients who were confirmed with higher bilirubin, GMT, and ammonia levels. No statistically significant differences were found for patients with a history of immune deficiency. One patient with preexisting liver disease developed fulminant infection resulting in death. Four hepatitis E patients with neurological symptoms had lower bilirubin levels.

Conclusions: The study cohort included predominantly older men. Genotype 3 was confirmed in all patients who underwent HEV RNA testing. Higher bilirubin, ammonia, and GMT levels were confirmed in patients with preexisting liver disease. Patients with neurological complications had lower bilirubin levels. One patient with preexisting liver disease died.

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来源期刊
Epidemiologie Mikrobiologie Imunologie
Epidemiologie Mikrobiologie Imunologie Medicine-Immunology and Allergy
CiteScore
0.90
自引率
0.00%
发文量
20
期刊介绍: The journal publishes original papers, information from practice, reviews on epidemiological and microbiological subjects. Sufficient space is devoted to diagnostic methods from medical microbiology, parasitology, immunology, and to general aspects and discussions pertaining to preventive medicine. It also brings translations and book reviews useful for medical doctors and research workers and professionals in public health.
期刊最新文献
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