阳和水煎华彩对肛瘘术后综合征组织修复的作用及机制研究

W U Yijuan, Sun Xinghong, Guo Haixia, Zhang Xiangan
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引用次数: 0

摘要

目的观察洋河煎剂华蟾素修复肛瘘术后阴证伤口的临床疗效和安全性:方法:将120例符合纳入标准的低位肛瘘术后阴性伤口缓慢愈合患者按照随机数字表法分为治疗组和对照组,治疗组60例,对照组60例。治疗组在常规治疗的基础上给予洋河煎剂华彩;对照组仅给予常规治疗,即用碘伏消毒创面,然后用无菌纱布覆盖。两组疗程均为 10 d,比较治疗后伤口分泌物评分、伤口肉芽组织评分、伤口中碱性成纤维细胞生长因子(bFGF)、转化生长因子β1(TGF-β1)和表皮生长因子(EGF)的表达水平、伤口愈合时间和临床疗效:两组患者的年龄和性别无明显差异(P>0.05)。术后第 10 天和第 15 天,治疗组的伤口分泌物评分高于对照组(P < 0.01)。两组在术后第 10 天和第 15 天的肉芽组织生长评分比较,治疗组优于对照组(P < 0.01)。术后第 10 天和第 15 天,治疗组 bFGF、TGF-β1 和 EGF 因子的表达水平均强于对照组。治疗组的伤口愈合时间明显短于对照组(P < 0.01)。比较两组治疗后的临床疗效,治疗组的总疗效明显高于对照组(P < 0.01):结论:洋河煎剂华蟾素治疗肛瘘术后阴证伤口愈合缓慢有显著疗效。结论:洋河煎剂华蟾素对肛瘘术后阴证伤口愈合缓慢有明显疗效,能改善伤口分泌物,促进伤口肉芽组织生长,缩短伤口愈合时间。其作用机制可能与控制伤口发炎有关。它与增加伤口组织中 bFGF、TGF-β1 和 EGF 的表达,促进伤口血管生成和成纤维细胞增殖有关。
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Study on the effect and mechanism of Yanghe decoction Huacai on tissue repair ofsyndrome after anal fistula surgery.

Objective: To observe the clinical efficacy and safety of Yanghe decoction Huacai for the repair of Yin syndrome wounds with slow-healing after anal fistula surgery.

Methods: A total of 120 patients with slow-healing negative wounds with after low-grade anal fistula surgery who met the inclusion criteria were divided into a treatment group and a control group based on a random number table method, with 60 patients in the treatment group and 60 patients in the control group. The treatment group was given Yanghe decoction Huacai in combination with routine treatment; the control group was only given routine treatment, in which the wound surface was disinfected with iodine, and then covered with sterile gauze. The course of treatment in both groups was 10 d. After treatment, the wound secretion score, wound granulation tissue score, the expression levels of basic fibroblast growth factor (bFGF), transforming growth factor β1 (TGF-β1), and epidermal growth factor (EGF) in the wound, wound healing time and clinical efficacy were compared.

Results: There was no significant difference in age or gender between the two groups (P > 0.05). On the 10th and 15th days after the surgery, the wound secretion scores were higher in the treatment group than in the control group (P < 0.01). Comparing the two groups at the 10th and 15th day after surgery, the granulation tissue growth scores in the treatment group were better than the in control group (P < 0.01). On the 10th and 15th day after operation, the expression levels of bFGF, TGF-β1 and EGF factors in the treatment group were stronger than those in the control group. The healing time of the wounds in the treatment group was significantly shorter than in the control group (P < 0.01). The clinical efficacy of the two groups after treatment was compared, and the overall efficacy of the treatment group was significantly higher than that of the control group (P < 0.01).

Conclusions: Yanghe decoction Huacai have significant efficacy in the treatment of slow-healing wounds with Yin syndrome after anal fistula surgery. It improves wound secretions, promotes the growth of wound granulation tissue, and shortens wound healing time. Its mechanism of action may be related to the control of wound inflammation. It is related to increasing the expression of bFGF, TGF-β1 and EGF in wound tissue, and promoting wound angiogenesis and fibroblast proliferation.

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