mTOR 将营养、炎症和寿命联系在一起。

IF 17 Q1 CELL BIOLOGY Nature aging Pub Date : 2024-07-26 DOI:10.1038/s43587-024-00681-5

Helena M. Cochemé, Jesús Gil

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摘要

Ortega-Molina 及其同事的一项研究利用 mTOR 活性轻度升高的小鼠模型，研究了营养信号增强对健康衰老的逐步影响过程。这些研究结果表明，mTOR 活性引起的最初实质损伤如何继发骨髓炎症，这一多阶段过程最终导致器官退化和寿命缩短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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mTOR links nutrients, inflammaging and lifespan

A study from Ortega-Molina and colleagues uses mouse models with mildly elevated mTOR activity to investigate the stepwise process by which increased nutrient signaling affects healthy aging. These findings show how initial parenchymal damage caused by mTOR activity is followed by secondary myeloid inflammation, a multistage process that culminates in organ deterioration and reduced lifespan.

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