全球最常见的 HLA 等位基因:基本概要

IF 2.2 4区 医学 Q3 HEMATOLOGY Best Practice & Research Clinical Haematology Pub Date : 2024-06-01 DOI:10.1016/j.beha.2024.101559
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引用次数: 0

摘要

对全球人类白细胞抗原(HLA)分子变异的全面了解对于人类群体遗传学研究和疾病关联研究至关重要,对于异体造血细胞移植等临床应用也不可或缺,因为确保供体和受体之间的 HLA 相容性至关重要。数十年来的 HLA 群体研究开发出了有用的数据库和生物信息学工具,使这一领域取得了巨大进步。然而,以合成的方式评估全球 HLA 群体的多样性仍然很困难。因此,我们在这里介绍一种基于约 2000 个数据集的新方法,通过提供在全球不同地区观察到的最常见 HLA 等位基因的基本概要来评估这种复杂性。这一新知识不仅可作为基础研究的基本参考,还可为从事移植领域工作的临床医生提供有效指导。
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The most frequent HLA alleles around the world: A fundamental synopsis

A comprehensive knowledge of human leukocyte antigen (HLA) molecular variation worldwide is essential in human population genetics research and disease association studies and is also indispensable for clinical applications such as allogeneic hematopoietic cell transplantation, where ensuring HLA compatibility between donors and recipients is paramount. Enormous progress has been made in this field thanks to several decades of HLA population studies allowing the development of helpful databases and bioinformatics tools. However, it is still difficult to appraise the global HLA population diversity in a synthetic way. We thus introduce here a novel approach, based on approximately 2000 data sets, to assess this complexity by providing a fundamental synopsis of the most frequent HLA alleles observed in different regions of the world. This new knowledge will be useful not only as a fundamental reference for basic research, but also as an efficient guide for clinicians working in the field of transplantation.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
期刊最新文献
Editorial Board From clones to immunopeptidomes: New developments in the characterization of permissive HLA-DP mismatches in hematopoietic cell transplantation Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation HLA structure and function in hematopoietic-cell transplantation Special issue 37.3: “Genetics and function of HLA and immune-related genes in hematopoietic cell transplantation and cellular immunotherapy”
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