帕金森病的神经炎症:关注 miRNA 与小胶质细胞之间的关系

IF 4.2 3区 医学 Q2 NEUROSCIENCES Frontiers in Cellular Neuroscience Pub Date : 2024-07-26 DOI:10.3389/fncel.2024.1429977
Ke Xu, Yuan Li, Yan Zhou, Yu Zhang, Yue Shi, Chengguang Zhang, Yan Bai, Shun Wang
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引用次数: 0

摘要

帕金森病(PD)是一种影响中枢神经系统(CNS)的流行性神经退行性疾病。神经炎症是帕金森病病理发展的关键因素。脊髓灰质炎的特点是存在活化的小胶质细胞和促炎因子水平升高,这在其病理过程中起着至关重要的作用。在帕金森病的免疫反应过程中,小胶质细胞的调节受到微小核糖核酸(miRNA)的显著影响。小胶质细胞的过度激活、持续的神经炎症以及大脑中巨噬细胞的异常极化都可归因于某些 miRNA 的失调。此外,还有一些 miRNAs 具有抑制神经炎症的能力。miRNAs 是一种小型非编码表观遗传调节因子,能够在正常和异常情况下调节小胶质细胞的活性。它们对促进神经元和小胶质细胞之间的交流也有重要影响。
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Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation is a crucial factor in the pathological advancement of PD. PD is characterized by the presence of activated microglia and increased levels of proinflammatory factors, which play a crucial role in its pathology. During the immune response of PD, microglia regulation is significantly influenced by microRNA (miRNA). The excessive activation of microglia, persistent neuroinflammation, and abnormal polarization of macrophages in the brain can be attributed to the dysregulation of certain miRNAs. Additionally, there are miRNAs that possess the ability to inhibit neuroinflammation. miRNAs, which are small non-coding epigenetic regulators, have the ability to modulate microglial activity in both normal and abnormal conditions. They also have a significant impact on promoting communication between neurons and microglia.
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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