T. A. Ivanova, E. M. Zubanova, P. S. Timashev, E. N. Golubeva
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EPR Study of Controlled Drug Release from PNIPAM and P(NIPAM-g-PLA) Globules
Abstract
Spin probe electron paramagnetic resonance spectroscopy was applied to estimate release kinetic patterns from globules formed in solutions of thermoresponsive polymers poly-N-isopropylacrylamide (PNIPAM) and graft copolymer based on N-isopropylacrylamide and oligolactide (P(NIPAM-g-PLA)) containing (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) spin probe as a drug model. It is shown that the main mechanism of TEMPO release from globules of thermoresponsive polymers in aqueous solutions above LSCT is Brownian diffusion.
期刊介绍:
Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.