Comparison between indocyanine green angiography and optical coherence tomography angiography for the detection of nonexudative macular neovascularization

What is known

•The prevalence of nonexudative MNV (neMNV) in the opposite eyes of patients with unilateral exudative neovascular AMD (nAMD) ranges from 6 to 27%. The importance of screening and in consequence close monitoring of a detected neMNV is underlined by the 14 to 23-fold risk of conversion to exudative disease, which they carry within the first two years of follow up.

•In the only study designed to compare the sensitivity of OCTA vs. ICGA, 3/41 eyes exhibited neMNV in both modalities and were therefore equally effective.

What is new

•This study showed that in a larger study population of 241 patients the sensitivity of ICGA and OCTA were equal with 80% (32/40) and 83% (33/40), although some neMNV would be missed by solely employing one imaging method.

•Accurate detection of neMNV using multimodal imaging should result in better monitoring of patients who are at high risk of conversion to exudative nAMD.