与生物膜相关的全膝关节置换术感染:预防、诊断和治疗。

E Carlos Rodriguez-Merchan
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引用次数: 0

摘要

生物膜相关植入物感染无疑是全膝关节置换术(TKA)中的一个相关挑战,我们的理解能力在稳步提高,新的管理方法也在不断开发。本文旨在回顾在应对 TKA 中生物膜形成细菌引起的感染方面取得的最重要进展。主要结论如下1)针对感染性 TKA 的基本管理技术包括开放性 DAIR(清创、抗生素和植入物保留)以及一期和二期翻修 TKA;2)持续局部抗生素灌注(CLAP)似乎可以降低假体周围关节感染(PJI)的风险;4)最近的一项体外研究显示,使用含有高达 100 毫克利福平的 PMMA(聚甲基丙烯酸甲酯)预防和治疗 TKA 后的 PJI 有良好效果。
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Biofilm Related Total Knee Arthroplasty Infection: Prevention, Diagnosis and Treatment.

Biofilm related implant infection is undoubtedly a relevant challenge in total knee arthroplasty (TKA) with our comprehension steadily progressing and novel management approaches being developed. The aim of this article was to review the most important advances in approaches to combat infections due to biofilm-forming bacteria in TKA. The main conclusions were the following: 1) Fundamental management techniques for infected TKA include open DAIR (debridement, antibiotics, and implant retention), and one and two-stage revision TKA; 2) Continuous local antibiotic perfusion (CLAP) appears to diminish the risk of periprosthetic joint infection (PJI); 3) Restraint of quorum sensing seems to avert PJI after TKA; 4) A recent in vitro study showed promising results in the prevention and management of PJI after TKA using PMMA [poly(methyl methacrylate)] loaded with up to 100 mg of rifampin.

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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
128
期刊介绍: The Archives of Bone and Joint Surgery (ABJS) aims to encourage a better understanding of all aspects of Orthopedic Sciences. The journal accepts scientific papers including original research, review article, short communication, case report, and letter to the editor in all fields of bone, joint, musculoskeletal surgery and related researches. The Archives of Bone and Joint Surgery (ABJS) will publish papers in all aspects of today`s modern orthopedic sciences including: Arthroscopy, Arthroplasty, Sport Medicine, Reconstruction, Hand and Upper Extremity, Pediatric Orthopedics, Spine, Trauma, Foot and Ankle, Tumor, Joint Rheumatic Disease, Skeletal Imaging, Orthopedic Physical Therapy, Rehabilitation, Orthopedic Basic Sciences (Biomechanics, Biotechnology, Biomaterial..).
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