慢性鼻窦炎鼻窦粘膜超硫化物的形成。

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY Laryngoscope Investigative Otolaryngology Pub Date : 2024-07-27 DOI:10.1002/lio2.1261

Jun Suzuki MD, PhD, Tomotaka Hemmi MD, PhD, Tomoaki Ida PhD, Seiryo Ogata PhD, Jun Yoshitake PhD, Tetsuro Matsunaga PhD, Tomoyasu Ishida BS, Yuki Numano MD, Yusuke Kusano MD, Ryoukichi Ikeda MD, PhD, Kazuhiro Nomura MD, PhD, Mitsuru Sugawara MD, PhD, Nobuo Ohta MD, PhD, Takaaki Akaike MD, PhD, Yukio Katori MD, PhD

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摘要

目的：氧化应激防御系统的破坏与多种疾病的发生有关。谷胱甘肽（GSH）和半胱氨酸（CysSH）等硫化合物是人体内具有代表性的抗氧化剂。最近，超硫化物（包括活性过硫化物和多硫化物）作为调节氧化应激和氧化还原信号的强效抗氧化剂受到关注。然而，它们与慢性鼻炎（CRS）发病机制的关系仍不清楚：为了明确每种 CRS 亚型鼻窦粘膜中硫化合物的变化，我们使用质谱分析法测量了接受鼻窦手术的对照组（9 人）、嗜酸性 CRS（ECRS）患者（13 人）和非 ECRS（nECRS）患者（11 人）鼻窦粘膜中硫化合物的水平：结果：ECRS患者的GSH和CysSH水平明显降低，氧化应激指标谷胱甘肽二硫化物（GSSG）/GSH比值升高。尽管超硫化物没有明显变化，但ECRS和nECRS患者的谷胱甘肽三硫化物（GSSSG）明显减少，而谷胱甘肽三硫化物是超硫化物的前体：该研究首次对正常和发炎鼻窦粘膜中的超硫化物进行了定量评估，表明硫化合物有助于CRS的发病机制：不适用。

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Supersulfide formation in the sinus mucosa of chronic rhinosinusitis

Objectives

Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body. Recently, supersulfides, including reactive persulfide and polysulfide species, have gained attention as potent antioxidants regulating oxidative stress and redox signaling. However, their involvement in the pathogenesis of chronic rhinosinusitis (CRS) remains unclear.

Methods

To clarify the changes in sulfur compounds within the sinus mucosa of each CRS subtype, we measured sulfur compound levels in the sinus mucosa of control individuals (n = 9), patients with eosinophilic CRS (ECRS) (n = 13), and those with non-ECRS (nECRS) (n = 11) who underwent sinus surgery using mass spectrometry.

Results

GSH and CysSH levels were significantly reduced, and the glutathione disulfide (GSSG)/GSH ratio, an oxidative stress indicator, was increased in patients with ECRS. Despite the absence of notable variations in supersulfides, patients with ECRS and nECRS exhibited a significant reduction in glutathione trisulfide (GSSSG), which serves as the precursor for supersulfides.

Conclusions

This study is the first quantitative assessment of supersulfides in normal and inflamed sinus mucosa, suggesting that sulfur compounds contribute to the pathogenesis of CRS.