限时进食会影响人体脂肪组织的脂肪动员。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-07-28 DOI:10.1002/oby.24057
Carolina Zambrano, Elena González-Alvarado, Diego Salmerón, Francisco Javier Ruiz-Ojeda, Juan Luján, Frank A. J. L. Scheer, Marta Garaulet
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引用次数: 0

摘要

目的:限时进食(TRE)是一种将食物摄入限制在特定时间窗口内的饮食方法,对新陈代谢有好处。然而,它对体重减轻的影响仍无定论。本研究的目的是利用人体脂肪组织(AT)培养物研究早期限时进食(eTRE)和延迟限时进食(dTRE)对脂肪动员的影响:方法:从 21 名重度肥胖症患者身上采集皮下 AT。方法:我们从 21 名重度肥胖症患者的皮下脂肪组织中采集了脂肪组织,通过测量脂肪组织培养物在对照组、eTRE、dTRE 和 24 小时禁食四种处理条件下的甘油释放量来评估脂肪动员情况:结果:TRE 对脂肪分解有明显影响(甘油释放量[平均值(标度)](单位:微摩尔/小时/克):对照组,0.05 [0.003];eTRE,0.10 [0.006];dTRE,0.08 [0.005];禁食,0.17 [0.008];P 结论:TRE 对脂肪分解有明显影响(甘油释放量[平均值(标度)](单位:微摩尔/小时/克):这项研究揭示了 TRE 对脂肪动员的潜在益处,可指导未来体重管理和代谢健康饮食策略的设计。
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Time-restricted eating affects human adipose tissue fat mobilization

Objective

Time-restricted eating (TRE), a dietary approach that confines food intake to specific time windows, has shown metabolic benefits. However, its impact on body weight loss remains inconclusive. The objective of this study was to investigate the influence of early TRE (eTRE) and delayed TRE (dTRE) on fat mobilization using human adipose tissue (AT) cultures.

Methods

Subcutaneous AT was collected from 21 participants with severe obesity. We assessed fat mobilization by measuring glycerol release in AT culture across four treatment conditions: control, eTRE, dTRE, and 24-h fasting.

Results

TRE had a significant impact on lipolysis (glycerol release [mean (SD)] in micromoles per hour per gram: control, 0.05 [0.003]; eTRE, 0.10 [0.006]; dTRE, 0.08 [0.005]; and fasting, 0.17 [0.008]; p < 0.0001). Both eTRE and dTRE increased lipolysis compared with the control group, with eTRE showing higher glycerol mobilization than dTRE during the overall 24-h time window, especially at the nighttime/habitual sleep episode (p < 0.0001). Further analysis of TRE based on fasting duration revealed that, independently of the time window, glycerol release increased with fasting duration (in micromoles per hour per gram: 8 h = 0.08 [0.001]; 12 h = 0.09 [0.008]; and 16 h of fasting = 0.12 [0.011]; p < 0.0001).

Conclusions

This study provides insights into the potential benefits of TRE on fat mobilization and may guide the design of future dietary strategies for weight management and metabolic health.

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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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