癌症中的线粒体金属肽酶 OMA1

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI:10.1016/bs.acr.2024.05.001
Gunjan Purohit, Polash Ghosh, Oleh Khalimonchuk
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引用次数: 0

摘要

我们对线粒体在细胞生理学中所扮演角色的理解发生了巨大变化--从单纯的细胞能量供应者转变为代谢和信号转导过程的重要调节者,尤其是在癌症等人类疾病的发展和进程中。本综述探讨了 OMA1(一种保守的、对氧化还原反应敏感的金属肽酶)在癌症生物学中的作用。OMA1 参与线粒体质量控制、氧化还原活动和应激反应,这突显了它作为癌症诊断和治疗新靶点的潜力。然而,我们对 OMA1 的调控和结构细节的了解并不全面,这给以 OMA1 为靶点进行治疗带来了持续的挑战。对 OMA1 的进一步研究有望揭示癌症机制和治疗策略的新见解。在本章中,我们将简要总结目前有关 OMA1、其氧化还原调控以及在某些癌症中的新作用的知识。
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Mitochondrial metallopeptidase OMA1 in cancer.

Our understanding of the roles that mitochondria play in cellular physiology has evolved drastically-from a mere cellular energy supplier to a crucial regulator of metabolic and signaling processes, particularly in the context of development and progression of human diseases such as cancers. The present review examines the role of OMA1, a conserved, redox-sensitive metallopeptidase in cancer biology. OMA1's involvement in mitochondrial quality control, redox activity, and stress responses underscores its potential as a novel target in cancer diagnosis and treatment. However, our incomplete understanding of OMA1's regulation and structural detail presents ongoing challenges to target OMA1 for therapeutic purposes. Further exploration of OMA1 holds promise in uncovering novel insights into cancer mechanisms and therapeutic strategies. In this chapter, we briefly summarize our current knowledge about OMA1, its redox-regulation, and emerging role in certain cancers.

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